Results 161 to 170 of about 421,672 (303)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

HAND TRANSPLANTATION: THE INFORMED CONSENT

, 2002
HAND TRANSPLANTATION: THE INFORMED ...
U. Genovese, R. Stucchi
core  

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation

, 2012
Chronic graft-versus-host disease (cGVHD) is a complication after minor antigen mismatched bone marrow transplantation (BMT) characterized by an autoimmune-type reaction in various organs.
Yumi Matsuzaki, Yoko Ogawa, Shigeto Shimmura, Yo Mabuchi, Sadafumi Suzuki, Yutaka Kawakami, Shinichiro Okamoto, Hideyuki Okano, Takaaki Inaba, Satoru Morikawa, Saori Yaguchi, Kazuo Tsubota, Tomonori Yaguchi   +12 more
core  

P31-A150 SARS-CoV-2 real time polymerase chain reaction testing of corneas from post-mortem SARS-CoV-2 positive donors

BMJ Open Ophthalmology, 2023
Marina Roncevic Krajina, Ivana Vidovic, Branka Golubic Cepulic, Ivana Juric, Elizabeta Zaplatic, Dolores Bukulin, Tomislav Popović, Ana Budimir   +7 more
doaj   +1 more source

Testicular tissue transplantation: from animal models to clinical application. [PDF]

Hum Reprod Open
De Beer E, Goossens E.
europepmc   +1 more source

A Systematic Review of Ovarian Tissue Transplantation Outcomes by Ovarian Tissue Processing Size for Cryopreservation. [PDF]

Front Endocrinol (Lausanne), 2022
Diaz AA, Kubo H, Handa N, Hanna M, Laronda MM.   +4 more
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Hydrogen-generating nanomodulators for metabolic repair and functional recovery in ovarian tissue transplantation. [PDF]

J Nanobiotechnology
Jiang M, Liu J, Zhao Y, Bai X, Yan H, Zeng Q, Wang L, Liao Y, Xiong D, Xie H, Luan Z, Yu L, He L, Zhou Z, Zhang G, Miao YB, Liu W.   +16 more
europepmc   +1 more source

Adult spinal cord tissue transplantation combined with local tacrolimus sustained-release collagen hydrogel promotes complete spinal cord injury repair. [PDF]

Cell Prolif, 2023
Zhao X, Gu R, Zhao Y, Wei F, Gao X, Zhuang Y, Xiao Z, Shen H, Dai J.   +8 more
europepmc   +1 more source