Results 51 to 60 of about 4,642,602 (301)

Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19

Frontiers in Immunology, 2021
COVID-19 disease caused by the SARS-CoV-2 virus is characterized by dysregulation of effector T cells and accumulation of exhausted T cells. T cell responses to viruses can be corrected by adoptive cellular therapy using donor-derived virus-specific T ...
Rachel S. Cooper, Alasdair R. Fraser, Linda Smith, Paul Burgoyne, Stuart N. Imlach, Lisa M. Jarvis, David M. Turner, Sharon Zahra, Marc L. Turner, John D. M. Campbell   +9 more
doaj   +1 more source

Tissue engineering; strategies, tissues, and biomaterials

Biotechnology and Genetic Engineering Reviews, 2017
Current tissue regenerative strategies rely mainly on tissue repair by transplantation of the synthetic/natural implants. However, limitations of the existing strategies have increased the demand for tissue engineering approaches. Appropriate cell source, effective cell modification, and proper supportive matrices are three bases of tissue engineering.
Bakhshandeh, Behnaz, Zarrintaj, Payam, Oftadeh, Mohammad Omid, Keramati, Farid, Fouladiha, Hamideh, Sohrabi-jahromi, Salma, Ziraksaz, Zarrintaj   +6 more
openaire   +3 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

A Comparative Study of Cell Culture Conditions during Conversion from Primed to Naive Human Pluripotent Stem Cells

Biomedicines, 2022
The successful reprogramming of human somatic cells into induced pluripotent stem cells (hiPSCs) represented a turning point in the stem cell research field, owing to their ability to differentiate into any cell type with fewer ethical issues than human ...
Irene Romayor, Lara Herrera, Maria Burón, Myriam Martin-Inaraja, Laura Prieto, Jone Etxaniz, Marta Inglés-Ferrándiz, Jose Ramon Pineda, Cristina Eguizabal   +8 more
doaj   +1 more source

Engineering vascularised tissues in vitro [PDF]

, 2008
Tissue engineering aims at replacing or regenerating tissues lost due to diseases or traumas (Langer and Vacanti, 1993). However, mimicking in vitro the physiological complexity of vascularized tissue is a major obstacle, which possibly contributes to ...
de Boer, Jan, Liu, J., Rivron, N.C., Rivron, N.C., Rouwkema, Jeroen, van Blitterswijk, Clemens   +5 more
core   +3 more sources

Characterising epithelial tissues using persistent entropy

, 2018
In this paper, we apply persistent entropy, a novel topological statistic, for characterization of images of epithelial tissues. We have found out that persistent entropy is able to summarize topological and geometric information encoded by \alpha ...
A Zomorodian, BI Shraiman, C Mazo, D Sánchez-Gutiérrez, H Adams, H Chintakunta, H Edelsbrunner, M Ferri, MC Gibson, MJ Jimenez, R Farhadifar   +10 more
core   +1 more source

Submission of Evidence on Online Violence Against Women to the UN Special Rapporteur on Violence Against Women, its Causes and Consequences, Dr Dubravka Šimonović [PDF]

, 2017
Figure S1. B3GALNT2 levels determined by W.B. and ROC curve. a–c Relative mRNA expression of B3GALNT2 in HCC tumor tissues and normal liver tissues obtained from GSE76427, GSE36376, and TCGA-LIHC datasets.
Jiangfan Zhou (5060249), Jianxin Gu (335766), Jing Wang (1228470), Lan Fang (5060246), Shushu Song (5060252), Tianxiao Yang (563355), Weicheng Wu (396588), Wenjuan Dai (1964755), Xixi Zheng (763131), Yilin Wang (490921)   +9 more
core   +6 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

West Nile Virus RNA in Tissues from Donor Associated with Transmission to Organ Transplant Recipients

Emerging Infectious Diseases, 2013
We identified West Nile virus (WNV) RNA in skin, fat, muscle, tendon, and bone marrow from a deceased donor associated with WNV transmission through solid organ transplantation. WNV could not be cultured from the RNA-positive tissues. Further studies are
Dianna M. Blau, Ingrid B. Rabe, Julu Bhatnagar, Rachel Civen, Kavita K. Trivedi, Dominique Rollin, Susan N. Hocevar, Matthew Kuehnert, J. Erin Staples, Sherif R. Zaki, Marc Fischer   +10 more
doaj   +1 more source

Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

eLife, 2020
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we describe a method that leverages high-dimensional phenotyping using CyTOF
Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Feng Hsiao, Tongcui Ma, Vincent Morcilla, Ashley Lee, Sushama Telwatte, Reuben Thomas, Whitney Tamaki, Benjamin Wheeler, Rebecca Hoh, Ma Somsouk, Poonam Vohra, Jeffrey Milush, Katherine Sholtis James, Nancie M Archin, Peter W Hunt, Steven G Deeks, Steven A Yukl, Sarah Palmer, Warner C Greene, Nadia R Roan   +23 more
doaj   +1 more source