Results 61 to 70 of about 3,581,912 (250)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessment frost resistance and winter hardiness of Persica Mill. species in Right-Bank of Forest-Steppe of Ukraine

Інтродукція Рослин, 2016
The purpose – to define potential frost resistance shoots and generative buds of members of Persica Mill. in the conditions of simulated low-temperature stress and actual (field) winter hardiness due selection and its expansion on northern regions of ...
I.M. Golubkovа
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Quantitative analysis of penicillins in porcine tissues, milk and animal feed using derivatisation with piperidine and stable isotope dilution liquid chromatography tandem mass spectrometry [PDF]

, 2010
Penicillins are used universally in both human and veterinary medicine. The European Union (EU) has established maximum residue levels (MRLs) for most ß-lactam antibiotics in milk and animal tissues and included them in the National Residue Monitoring ...
Eric O. van Bennekom, Holthoon, F.L., van, Tina Zuidema, van Rhijn, J.A., Bennekom, E.O., van, van Bennekom, E.O., Rhijn, J.A., van, Zuidema, T., Heskamp, H.H., Frédérique van Holthoon, van Holthoon, F.L., Henri Heskamp, Hans A. van Rhijn, Patrick P. J. Mulder, Mulder, P.P.J.   +14 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals

Юг России: экология, развитие
The purpose of this work was to study the influence of new synthesized organotellurium compounds (TOCs) on the intensity of oxidative processes in the body of mammals – in this case, the blood and liver of rats.The experiments were performed on white ...
A. I. Israpilova, A. M. Dzhafarova, A. A. Adieva, G. M. Abakarov, N. O. Guseynova, U. Y. Khalimbekova, M. D. Astaeva, K. S. Bekshokov   +7 more
doaj   +1 more source

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia

Pharmaceutical Biology, 2018
Context: Galangin, a natural flavonoid, is found in honey and Alpinia officinarum Hance (Zingiberaceae). Galangin has antiviral, antimicrobial, antidiabetic and anticancer properties, without side effects.
Amal A. Aloud, Veeramani Chinnadurai, Chandramohan Govindasamy, Mohammed A. Alsaif, Khalid S. Al-Numair   +4 more
doaj   +1 more source