Results 61 to 70 of about 4,593,500 (285)

West Nile Virus RNA in Tissues from Donor Associated with Transmission to Organ Transplant Recipients

Emerging Infectious Diseases, 2013
We identified West Nile virus (WNV) RNA in skin, fat, muscle, tendon, and bone marrow from a deceased donor associated with WNV transmission through solid organ transplantation. WNV could not be cultured from the RNA-positive tissues. Further studies are
Dianna M. Blau, Ingrid B. Rabe, Julu Bhatnagar, Rachel Civen, Kavita K. Trivedi, Dominique Rollin, Susan N. Hocevar, Matthew Kuehnert, J. Erin Staples, Sherif R. Zaki, Marc Fischer   +10 more
doaj   +1 more source

Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

eLife, 2020
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we describe a method that leverages high-dimensional phenotyping using CyTOF
Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Feng Hsiao, Tongcui Ma, Vincent Morcilla, Ashley Lee, Sushama Telwatte, Reuben Thomas, Whitney Tamaki, Benjamin Wheeler, Rebecca Hoh, Ma Somsouk, Poonam Vohra, Jeffrey Milush, Katherine Sholtis James, Nancie M Archin, Peter W Hunt, Steven G Deeks, Steven A Yukl, Sarah Palmer, Warner C Greene, Nadia R Roan   +23 more
doaj   +1 more source

Sparse multi-view matrix factorisation: a multivariate approach to multiple tissue comparisons

, 2015
Gene expression levels in a population vary extensively across tissues. Such heterogeneity is caused by genetic variability and environmental factors, and is expected to be linked to disease development. The abundance of experimental data now enables the
Montana, Giovanni, Wang, Zi, Yuan, Wei
core   +1 more source

Transient Displacement Response to Pulse Excitations on Periodontal Tissues [PDF]

, 1988
In the field of dental study it is most fundamental and necessary to estimate the condition of periodontium. In order to examine a mechanical characteristics of periodontium, the theoretical displacement response to periodontal mechanical model (three ...
Isayama, Yoshiharu, Oka, Hisao, Yamamoto, Tatsuma   +2 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Lactylation: the novel histone modification influence on gene expression, protein function, and disease

Clinical Epigenetics
Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone a resurgence in scientific interest since the discovery of the Warburg effect in tumor cells.
Yue Hu, Zhenglin He, Zongjun Li, Yihan Wang, Nan Wu, Hongyan Sun, Zilong Zhou, Qianying Hu, Xianling Cong   +8 more
doaj   +1 more source

Analysis of Gene Regulatory Network and Transcription Factors in Different Tissues of the Stropharia rugosoannulata Fruiting Body

Journal of Fungi
Stropharia rugosoannulata is a mushroom that is rich in nutrients and has a pleasant flavor. Its cultivation area is expanding rapidly due to its simplicity and diversity.
Jia Lu, Jing Yan, Na Lu, Jiling Song, Jiayao Lin, Xiaohua Zhou, Xuebing Ying, Zhen Li, Zufa Zhou, Fangjie Yao   +9 more
doaj   +1 more source

Integrated response of antioxidant biomarkers in the liver and white muscle of European hake (Merluccius merluccius L.) females from the Adriatic sea with respect to environmental influences [PDF]

Archives of Biological Sciences, 2018
We investigated the integrated response of antioxidant defense enzymes (total superoxide dismutase (TotSOD), manganese-containing superoxide dismutase (MnSOD), copper-zinc-containing superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (
Pavlović Slađan Z., Borković-Mitić Slavica S., Radovanović Tijana B., Gavrilović Branka R., Despotović Svetlana G., Gavrić Jelena P., Prokić Marko D., Saičić Zorica S.   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source