Results 161 to 170 of about 612,065 (387)

Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model

open access: yesAdvanced Healthcare Materials, EarlyView.
A modular, triple‐action titanium implant is developed to prevent implant‐associated infections by repelling bacteria, killing pathogens, and enhancing tissue integration. Coatings with phage cocktails targeting P. aeruginosa and S. aureus show significant bacterial reduction and improved survival in a mouse sepsis model.
Martin Stark   +9 more
wiley   +1 more source

Omics-driven identification and elimination of valerolactam catabolism in Pseudomonas putida KT2440 for increased product titer

open access: gold, 2019
Mitchell G. Thompson   +13 more
openalex   +2 more sources

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

open access: yesAdvanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li   +8 more
wiley   +1 more source

Norbornene Homopolymerization Limits Cell Spreading in Thiol–Ene Photoclick Hydrogels

open access: yesAdvanced Healthcare Materials, EarlyView.
Thiol–norbornene click reactions are often used in the development of cell‐permissive 3D hydrogels. However, ene–ene crosslinks in other thiol–ene systems are known to limit permissivity. This study demonstrates the negative effects of norbornene homopolymerization on 3D cell spreading and circumvents the issue by modulating polymer degree of ...
James L. Gentry, Steven R. Caliari
wiley   +1 more source

Differing Transcriptomic Responses in High Titer versus Low Titer Aedes aegypti Mosquitoes after Oral Infection with Sindbis Virus

open access: yesViruses
Oral infection of mosquitoes by arboviruses often results in a large degree of variation in the amount of infectious virus between individual mosquitoes, even when the mosquitoes are from inbred laboratory strains.
Peter Hodoameda   +3 more
doaj   +1 more source

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

open access: yesAdvanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang   +7 more
wiley   +1 more source

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