Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
High-throughput optimization of antibody production in CHO cells by tuning heavy- and light-chain promoter strength. [PDF]
Front Bioeng BiotechnolRahimi M +4 more
europepmc +1 more source
Quantification of rose rosette emaravirus (RRV) titers in eriophyoid mites: insights into viral dynamics and vector competency [PDF]
Tobiasz Druciarek +2 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement +12 more
wiley +1 more source
Systematic review and data-driven insights into CHO cell engineering for next-generation antibody production. [PDF]
MAbsSchulz A +5 more
europepmc +1 more source
A Biomimetic Buffering Hydrogel Scaffold for Long‐Term Culture of Patient‐Derived Tumor Organoids
Advanced Healthcare Materials, EarlyView.A biomimetic fibrous buffering hydrogel controls the local acidification at the tumoroid/hydrogel interface at the physiologically relevant level over 21‐day culture. The buffering effect promotes cancer cell proliferation in the tumoroids and supports the structural integrity and mechanical properties of the hydrogel scaffold over long‐term tumoroid ...
Elizaveta Gusarova +5 more
wiley +1 more source
Antibiotic-free high-yield (-)-α-bisabolol production in <i>Serratia marcescens</i> via metabolic engineering and genomic integration of mevalonate pathway genes. [PDF]
Synth Syst BiotechnolLi W +7 more
europepmc +1 more source
Seropositivity of Anti-HBs Titer Among College Students Several Years After Completion of the Primary Hepatitis B Vaccination Series [PDF]
Monique Valerio-Fabros, Jay Ron Padua
openalex +1 more source