Results 221 to 230 of about 612,065 (387)

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

open access: yesAdvanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong   +16 more
wiley   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

open access: yesAdvanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li   +13 more
wiley   +1 more source

You mob my owl, I’ll mob yours: birds play tit-for-tat game [PDF]

open access: gold, 2012
Tatjana Krama   +5 more
openalex   +1 more source

CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3

open access: yesAdvanced Science, EarlyView.
This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).
Houliang Zhang   +10 more
wiley   +1 more source

Enhanced Influenza Vaccines Extend A(H3N2) Antibody Reactivity in Older Adults but Prior Vaccination Effects Persist. [PDF]

open access: yesClin Infect Dis
Fox A   +15 more
europepmc   +1 more source

Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells

open access: green
Martina Pistek   +4 more
openalex   +2 more sources

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