Results 281 to 290 of about 638,613 (387)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Long-Term Clinical Outcomes of ABO-Incompatible Kidney Transplantation in Patients With High Baseline Anti-A/B Antibody Titers. [PDF]

J Korean Med Sci
Eum SH, Lee H, Ko EJ, Min JW, Ban TH, Yoon HE, Shin SJ, Chung BH.   +7 more
europepmc   +1 more source

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source

A Comparison of Techniques Used for Antibody Titer Determination in Screening for Fetal Anemia Secondary to Red Blood Cell Alloimmunization. [PDF]

Transfus Med Hemother
Dysart S, Forde B, Thant M, Liu J, Staker S, Markham K.   +5 more
europepmc   +1 more source

Assessing Antibody Strength: Comparison of MFI, C1q, and Titer Information

American Journal of Transplantation, 2015
A. Tambur, Nancy D. Herrera, K. Haarberg, M. Cusick, R. A. Gordon, J. Leventhal, J. Friedewald, D. Glotz   +7 more
semanticscholar   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Metabolic engineering of endogenous MEP pathway for enhanced lycopene production in <i>Escherichia coli</i>. [PDF]

Synth Syst Biotechnol
Xu X, Xing H, Zhi H, Qin C, Deng Y, Wei W, Huang C.   +6 more
europepmc   +1 more source

Great tit (Parus major) breeding in fire-prone oak woods: differential effects of post-fire conditions on reproductive stages

, 2011
Enrico Bellia, Daniela Campobello, Maurizio Sarà   +2 more
openalex   +2 more sources

Label‐Free and Immobilization‐Free Protein‐Binding Assays by Ultraviolet Transient Absorption Microscopy

Advanced Science, EarlyView.
A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Jianghao Shen, Qiangqiang Wang, Fan Wu, Yang Gao, Lu Lan, Pu Wang   +5 more
wiley   +1 more source

Improved de novo production of prostaglandin F_2α from glucose with engineered Yarrowia lipolytica strains. [PDF]

Commun Biol
He GW, Ding LM, Fan X, Wang C, Lu XY, Tian Y, Ji XJ, Huang H, Liu HH.   +8 more
europepmc   +1 more source