Results 281 to 290 of about 438,789 (339)

Feasibility and population exposure of 5‐fluorouracil using therapeutic drug monitoring (PREDICT‐5FU): A multicentre clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis, Michael Michael, Howard Gurney, Ian Olver, Nicholas Zdenkowski, Stephen Ackland, Craig Kukard, Madawa Jayawardana, S. Sandun M. Silva, Marliese Alexander, Jeanne Tie, Peter Galettis, Jennifer H. Martin   +12 more
wiley   +1 more source

Pharmacology and relevant drug interactions of metamizole

British Journal of Clinical Pharmacology, EarlyView.
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman, Linda C. Hendriksen, Irma M. Rigter, Markus W. Hollmann   +3 more
wiley   +1 more source

Balancing Doses of EL222 and Light Improves Optogenetic Induction of Protein Production in Komagataella phaffii

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Komagataella phaffii, also known as Pichia pastoris, is a powerful host for recombinant protein production, in part due to its exceptionally strong and tightly controlled PAOX1 promoter. Most K. phaffii bioprocesses for recombinant protein production rely on PAOX1 to achieve dynamic control in two‐phase processes.
Shannon M. Hoffman, Sebastián Espinel‐Ríos, Sarah K. Kwartler, Makoto A. Lalwani, José L. Avalos   +4 more
wiley   +1 more source

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing. [PDF]

Biotechnol Bioeng
Green EA, Fu Q, Ndahiro N, Leibiger TM, Wang Y, Lee Y, Lee KH, Betenbaugh M, Yoon S, McNally DJ.   +9 more
europepmc   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Improving AAV Production Yield and Quality for Different Serotypes Using Distinct Processing Methods. [PDF]

ACS Omega
Khaparde A, Patra R, Roy S, Babu G R S, Ghosh A.   +4 more
europepmc   +1 more source

Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT There is increasing interest in the development of intensified processes that can provide significant reductions in manufacturing costs for monoclonal antibody (mAb) products. This study examines the performance of an integrated membrane process that combines single‐pass tangential flow filtration (SPTFF) with high‐performance countercurrent ...
Mirko Minervini, Aylin Mohammadzadehmarandi, Ali Behboudi, Sheldon F. Oppenheim, Andrew L. Zydney   +4 more
wiley   +1 more source

Even low levels of anticardiolipin antibodies are associated with pregnancy-related complications: A monocentric cohort study. [PDF]

Acta Obstet Gynecol Scand
Matraszek VV, Krofta L, Hromadnikova I.
europepmc   +1 more source

Usutu Virus Antibody Dynamics in Naturally Infected Blackbirds, the Netherlands, 2016-2018. [PDF]

Emerg Infect Dis
de Bruin E, van Irsel J, Chandler F, Kohl R, van de Voorde T, van der Linden A, de Boer F, Koopmans M, van der Jeugd H, Reusken C.   +9 more
europepmc   +1 more source

Development and optimization of human T-cell leukemia virus-specific antibody-dependent cell-mediated cytotoxicity (ADCC) assay directed to the envelope protein. [PDF]

J Virol
Pise-Masison CA, Rahman MA, Masison DC, Gutowska A, Moles R, Bissa M, Sarkis S, Schifanella L, Zhou T, Jones J, Jacobson S, Franchini G.   +11 more
europepmc   +1 more source