Results 291 to 300 of about 612,065 (387)

Ecdysone Titer Determined by 3DE-3β-Reductase Enhances the Immune Response in the Silkworm

open access: yesJournal of Immunology, 2016
Wei Sun   +3 more
semanticscholar   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

open access: yesAdvanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu   +10 more
wiley   +1 more source

Optimization of the VSV-G backbone for amino terminal fusion with nanobodies allowing its specific retargeting to HER2 receptors. [PDF]

open access: yesMol Ther Oncol
Duquénois I   +9 more
europepmc   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

open access: yesAdvanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling   +13 more
wiley   +1 more source

Plasma protein increase as a chronological aging factor in healthy toy poodles. [PDF]

open access: yesSci Rep
Ozaki S   +7 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

open access: yesAdvanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou   +18 more
wiley   +1 more source

Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessment. [PDF]

open access: yesSignal Transduct Target Ther
Yang X   +11 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

Statistical optimization and scaled-up bioreactor fermentation for enhanced edible oil production from palm date waste by Rhodotorula glutinis KAEC-61. [PDF]

open access: yesSci Rep
Elazzazy AM   +8 more
europepmc   +1 more source

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