Results 321 to 330 of about 598,693 (386)

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Long-Term Retrospective Analysis of Parvovirus B19 Infections in Blood Donors (2012-2024): Significant Increase in Prevalence Following the SARS-CoV-2 Pandemic. [PDF]

Diagnostics (Basel)
Oeller M, Kartal O, Trifonova I, Held N, Hoeggerl AD, Neureiter H, Lauth W, Grabmer C, Rohde E, Laner-Plamberger S.   +9 more
europepmc   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Biological characterization and antibacterial effects of a novel virulent <i>Acinetobacter baumannii</i> phage strain vB_Aba_QH4 <i>in vitro</i> and <i>in vivo</i>. [PDF]

Front Microbiol
Ruizhe L, Peng C, Zian L, Jianwu Z, Xiangren A.   +4 more
europepmc   +1 more source

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
wiley   +1 more source

Optimizing phage therapy for Salmonella Pullorum: dosage, timing, and pharmacokinetics define treatment efficacy in SPF chickens. [PDF]

Poult Sci
Li L, Zhang M, Cai Y, Liu Z, Tang Z, Zhang Z, Liu Y, Zhao C, Yu X, Petersen B, Sicheritz-Pontén T, Clokie MRJ, Liu Y.   +12 more
europepmc   +1 more source

Estrogen Alleviates Sevoflurane‐Induced Neurotoxicity by Inhibiting ERα‐Tau Binding

Advanced Science, EarlyView.
Sevoflurane‐induced neurotoxicity exhibits sex differences, and estrogen can mitigate these effects; however, its protective action appears to be time‐window dependent, which may be related to the competitive binding of estrogen and Tau to ERα. Abstract Sevoflurane‐induced neurotoxicity is age‐dependent, but the role of sex differences is unclear ...
Feixiang Li, Bingqing Gong, Zichen Song, Nuo Yang, Yuming Liu, Jinqin Zhang, Dujuan Li, Yongyan Yang, Yonghao Yu   +8 more
wiley   +1 more source

A modelling framework to improve antibody titer estimation from dilution series data: application to RSV Foci Reduction Neutralization Tests

Wang Y, Wang Q, Wymant C, Zou J, Yi L, Xu M, Hay JA, Yu H.   +7 more
europepmc   +1 more source

Assessment of Oral Poliovirus Vaccine Viability and Titer at Delivery Points in Kinshasa, the Democratic Republic of the Congo: Implications for Cold Chain Management. [PDF]

Vaccines (Basel)
Kashitu-Mujinga G, Makaka-Mutondo A, Matondo-Kuamfumu M, Mambu-Mbika F, Bulabula-Penge J, Kabeya-Mampuela T, Nkawa F, Wanet-Tayele G, Nsunda-Makanzu B, Nsele-Muntatu P, Kabamba L, Nkuba-Ndaye A, Cikomola AMWB, Mukamba-Musenga E, Ahuka-Mundeke S.   +14 more
europepmc   +1 more source

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects against In Vivo Infection via the Induction of Broad‐Spectrum PRRSV Neutralization

Advanced Science, EarlyView.
This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A. Hiscox, James P. Stewart, Yani Sun, Qin Zhao   +12 more
wiley   +1 more source