Results 31 to 40 of about 436,080 (341)

Rapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samples

mAbs, 2020
The success of monoclonal antibody (mAb) therapeutics have increased pharmaceutical investment in mAb production, which has led to a greater demand of technologies to efficiently characterize these biotherapeutics.
Zachary D. Dunn, Jayesh Desai, Gabriel M. Leme, Dwight R. Stoll, Douglas D. Richardson   +4 more
doaj   +1 more source

Bimodal antibody-titer decline following BNT162b2 mRNA anti-SARS-CoV-2 vaccination in healthcare workers of the INT – IRCCS “Fondazione Pascale” Cancer Center (Naples, Italy)

Infectious Agents and Cancer, 2022
Background Both SARS-CoV-2 mRNA-based vaccines [BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)] have shown high efficacy, with very modest side effects in limiting transmission of SARS-CoV-2 and in preventing the severe COVID-19 disease ...
Maria Antonietta Isgrò, Giusy Trillò, Luigi Russo, Anna Lucia Tornesello, Luigi Buonaguro, Maria Lina Tornesello, Leonardo Miscio, Nicola Normanno, Attilio Antonio Montano Bianchi, Franco Maria Buonaguro, Ernesta Cavalcanti, the anti-COVID-19 INT Task Force   +11 more
doaj   +1 more source

Cross-validation of chemical and genetic disruption approaches to inform host cellular effects on Wolbachia abundance in Drosophila

Frontiers in Microbiology
IntroductionEndosymbiotic Wolbachia bacteria are widespread in nature, present in half of all insect species. The success of Wolbachia is supported by a commensal lifestyle.
Zinat Sharmin, Zinat Sharmin, Hani Samarah, Hani Samarah, Rafael Aldaya Bourricaudy, Rafael Aldaya Bourricaudy, Laura Ochoa, Laura Ochoa, Laura Renee Serbus, Laura Renee Serbus, Laura Renee Serbus   +10 more
doaj   +1 more source

Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation

Toxins, 2016
While decades of research have focused on snake venom proteins, far less attention has been paid to small organic venom constituents. Using mostly pooled samples, we surveyed 31 venoms (six elapid, six viperid, and 19 crotalid) for spermine, spermidine ...
Steven D. Aird, Alejandro Villar Briones, Michael C. Roy, Alexander S. Mikheyev   +3 more
doaj   +1 more source

Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus. [PDF]

, 2014
Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases.
Anderson, Andrew F. van den Hurk, Armstrong, Armstrong, Beebe, Beebe, Bennett, Bosio, Chevillon, Elizabeth A. McGraw, Endersby, Failloux, Forrester, Francesca D. Frentiu, Frentiu, Gubler, Gubler, Gubler, Guzman, Halstead, Halstead, Hanna, Holmes, Holmes, Huber, Kien, Knox, Kyle, Lambrechts, Lambrechts, Moreira, Neff, Nigel W. Beebe, Parameswaran, Paupy, Rosen, Ross, Scott L. O'Neill, Tat Siong Ng, Thomas Walker, Van Den Hurk, Vasilakis, Vazeille-Falcoz, Warrilow, Xi, Ye, Yixin H. Ye, Yoon   +47 more
core   +2 more sources

Seasonal Variation in Grapevine Red Blotch Virus Titer in Relation to Disease Symptom Expression in Vineyards

Phytobiomes Journal
Grapevine red blotch virus (GRBV) is the causative agent of red blotch disease. Limited information is available on the seasonal variation of GRBV titer in relation to disease symptom expression in vineyards across the United States.
Madison Flasco, Victoria Hoyle, Garner Powell, Jacob Seiter, Alice Wise, Elizabeth J. Cieniewicz, Marc Fuchs   +6 more
doaj   +1 more source

Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort [PDF]

, 2013
The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in ...
Cane, Patricia, Medley, Graham, Mutunga, M. N., Nokes, D. James, Okiro, Emelda A., Sande, Charles J.   +5 more
core   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Immunogenicity and tolerability of an MF59-adjuvanted, egg-derived, A/H1N1 pandemic influenza vaccine in children 6-35 months of age [PDF]

, 2014
Background: Vaccines against pandemic A/H1N1 influenza should provide protective immunity in children, because they are at greater risk of disease than adults.
Abarca, Katia, Arora, Ashwani, Della Cioppa, Giovanni, Kieninger-Baum, Dorothee, Knuf, Markus, Lattanzi, Maria, Leroux-Roels, Geert, Pedotti, Paola, Rivera, Luis, Rümke, Hans C   +9 more
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source