Results 141 to 150 of about 256,556 (266)

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Conformational Transduction Amplification in a Biomimetic Polyelectrolyte for Ultrasensitive Imaging of Iron Metabolism

Advanced Science, EarlyView.
This work designs a peptide‐free polyelectrolyte with stable, switchable conformations and near‐infrared fluorescence in water. It harnesses a cooperative Fe3+‐triggered sheet‐to‐helix transition to generate nonlinear fluorescence quenching, enabling the ultrasensitive, real‐time visualization of Fe3+ ion distribution and metabolic trafficking at ...
Yeqiang Zhou, Danqi Yang, Yiwei Wang, Shuangyan Li, Fan Fan, Jiayu Zou, Cheng Zhang, Yang Liu, Hong Tan, Mingming Ding   +9 more
wiley   +1 more source

Determination of water in organic solvents by ligand-exchange reaction of Tris(2-methyl-8-quinolinolato)indium(III) complex. [PDF]

Anal Sci
Watanabe N, Uehara N, Inagawa A.
europepmc   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Chalcogen-bonding-mediated chiral recognition and enantioenrichment of organoselenocyanates. [PDF]

Chem Sci
Wang T, Hao A, Xing P.
europepmc   +1 more source

3D‐Mixer‐Assisted High‐Entropy Doping of LiNiO2 for Co‐Free Ni‐Rich Cathodes in Lithium‐Ion Batteries

Advanced Science, EarlyView.
High‐entropy doping of Co‐free Ni‐rich LiNiO2 cathodes is achieved through a scalable 3D mixing process. Multi‐element incorporation stabilizes the layered structure, alleviates Li/Ni disorder and electrode swelling, and enhances cycling stability. This approach underscores the potential of high‐entropy strategies to deliver structurally robust and ...
Seung Ri Kim, Thillai Govindaraja Senthamaraikannan, Jun Jae Myeong, Hyung Do Kim, Dong‐Hee Lim, Eun Mi Kim, Sang Mun Jeong   +6 more
wiley   +1 more source

Use of Weighted Blankets as Adjunct Therapy for Symptom Reduction Among Emergency Department Patients Receiving Buprenorphine for Opioid Withdrawal. [PDF]

Acad Emerg Med
LeSaint KT, Ager EE, Kaul P, Geier C, Smollin CG.   +4 more
europepmc   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study. [PDF]

PLoS Med
Garg R, Luo J, Bozinoff N, Sproule B, Antoniou T, Wyman J, Leece P, Munro C, Besharh J, Gomes T.   +9 more
europepmc   +1 more source

Metal Ion‐Induced Fast Gelation of 2D MnO2 Nanosheets With Cationic Vacancies for Durable Aqueous Zinc‐Ion Batteries

Advanced Science, EarlyView.
We report Mn‐deficient aerogels by inducing the first gelation of MnO2 nanosheets in solution using divalent metal ions as crosslinking agents, thereby inhibiting nanosheet restacking and enhancing surface utilization. Benefiting from abundant Mn vacancies and 3D porous structures, the A‐MnO2 cathode exhibits improved conductivity, fast reaction ...
Yalei Wang, Xinyu Huang, Shulong Chang, Bowen Li, Caichao Ye, Feng Yang, Yahui Xue   +6 more
wiley   +1 more source