Results 151 to 160 of about 5,780 (184)

The kinin system in the envenomation caused by the Tityus serrulatus scorpion sting

Toxicology and Applied Pharmacology, 2004
Several lines of evidence in experimental animals indicate that the kinin system may participate in the pathogenesis of envenomation by the Tityus serrulatus (Ts) scorpion sting, but there are no studies in humans with regard to this system. In this study, we evaluated the plasma levels of high-molecular (HKg) and low-molecular (LKg) weight kininogens (
Y D M, Fukuhara, R, Dellalibera-Joviliano, F Q C, Cunha, M L, Reis, E A, Donadi   +4 more
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Reproductive toxic effects of Tityus serrulatus scorpion venom in rats

Reproductive Toxicology, 2008
Tityus serrulatus is the most venomous scorpion in Brazil. Little is known about the effect of maternal exposure to the venom on fetal development. We investigated the effect of low to moderate doses of the venom (0.3 or 1.0 mg/kg s.c. on either day 5 or day 10 of gestation) on pregnant rats and on their offspring.
Karen, Cruttenden, Ana Leonor A, Nencioni, Maria Martha, Bernardi, Valquiria A C, Dorce   +3 more
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Tityus serrulatus venom peptidomics: Assessing venom peptide diversity

Toxicon, 2008
MALDI-TOF-TOF and de novo sequencing were employed to assess the Tityus serrulatus venom peptide diversity. Previous works has shown the cornucopia of molecular masses, ranging from 800 to 3000Da, present in the venom from this and other scorpions species. This work reports the identification/sequencing of several of these peptides. The majority of the
Breno, Rates, Karla K F, Ferraz, Márcia H, Borges, Michael, Richardson, Maria Elena, De Lima, Adriano M C, Pimenta   +5 more
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Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats

Toxicon, 1993
This study was designed to investigate the convulsant effects of T. serrulatus scorpion venom in rats. Pretreatment of rats with venom increased the minimum convulsant dose of picrotoxin, impaired convulsion generalization and displaced to the left the dose-response curve for picrotoxin.
M R, Sandoval, V A, Dorce
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Lung oedema induced by Tityus serrulatus scorpion venom in the rat

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1997
The effects of drugs were investigated on the induction of acute lung oedema by scorpion Tityus serrulatus venom in male Wistar rats (200-230 g) anaesthetized with sodium pentobarbital (40 mg/kg, i.p.). Intravenous (i.v.) injection of scorpion venom (0.5 mg/kg) into 12 rats induced arterial hypertension and severe lung oedema, whereas i.v. injection of
I M, De Matos, O A, Rocha, R, Leite, L, Freire-Maia   +3 more
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Immune cells recruitment and activation by Tityus serrulatus scorpion venom

Toxicon, 2011
Despite several studies showed that the Tityus serrulatus scorpion venom (Tsv) induces an inflammatory response, just a few have investigated the effect of the venom on the immune response. Therefore, the aim of this study was to evaluate alterations of venom application on lymphoid organs and on the recruitment and activation of cells and also on the ...
Eder M S, Fialho, Márcia C G, Maciel, Arlley C B, Silva, Aramys S, Reis, Anne Karine M, Assunção, Thiare S, Fortes, Lucilene A, Silva, Rosane N M, Guerra, Fabio H, Kwasniewski, Flávia R F, Nascimento   +9 more
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Effect of the venom of the scorpion Tityus serrulatus on adrenal gland catecholamines

Toxicon, 1968
Abstract A sublethal dose of the venom of the scorpion Tityus serrulatus produced a depletion of adrenal gland catecholamines. This effect was blocked on denervation of the adrenals. The action of the venom on the chromaffin granules in vitro was not observed. Certain fractions of the venom elicited the same effects as the whole venom.
M C, Henriques, G, Gazzinelli, C R, Diniz, M V, Gomez   +3 more
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Acute pulmonary edema after Tityus serrulatus scorpion sting in children

The American Journal of Cardiology, 1993
Acute pulmonary edema due to scorpion toxins has been attributed to acute left ventricular failure resulting from massive catecholamine release or myocardial damage induced by the venom.1–3 It has been proposed that pulmonary edema could also result from increased pulmonary vascular permeability produced by vasoactive substances that may be released by
C F, Amaral, N A, de Rezende, L, Freire-Maia   +2 more
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Ipomoea asarifolia neutralizes inflammation induced by Tityus serrulatus scorpion venom

Journal of Ethnopharmacology, 2014
Envenoming caused by scorpion sting is a serious public health problem. In Brazil, 13,038 accidents caused by venomous animals have been reported. Of this total, 53% of the cases and 14 deaths were caused by scorpions. Furthermore, Tityus serrulatus (Buthidae) is the most dangerous scorpion due to the high toxicity of its venom.
Maira Conceição Jerônimo de Souza, Lima, Mariana Angélica Oliveira, Bitencourt, Allanny Alves, Furtado, Hugo Alexandre, Oliveira Rocha, Ruth Medeiros, Oliveira, Arnóbio Antônio, da Silva-Júnior, Eryvaldo Sócrates, Tabosa do Egito, Denise Vilarinho, Tambourgi, Silvana Maria, Zucolotto, Matheus de Freitas, Fernandes-Pedrosa   +9 more
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The effect of dithiothreitol on the activity of tityustoxin from the scorpion Tityus serrulatus venom

Toxicology Letters, 1994
The acetylcholine (ACh) liberating effect on rat brain slices of tityustoxin, an alpha toxin from the scorpion Tityus serrulatus venom, was measured in the absence and presence of dithiothreitol (DTT). The rate of net ACh liberation by toxin concentrations of 2 nmol in 5 ml of organ bath, was 7.5 +/- 0.09 nmol g-1 min-1. If DTT at a final concentration
A M, Silva, G, Novaes, I F, Heneine
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