Results 141 to 150 of about 5,780 (184)

Renal effects and vascular reactivity induced by Tityus serrulatus venom

Toxicon, 2005
Tityus serrulatus, popularly known as yellow scorpion, is one of the most studied scorpion species in South America and its venom has supplied some highly active molecules. The effects of T. serrulatus venom upon the renal physiology in human showed increased renal parameters, urea and creatinine.
Alves, R. D., do Nascimento, NRF, Barbosa, PSF, Kerntopf, M. R., Lessa, LMA, de Sousa, C. M., Martins, R. D., Sousa, D. F., de Queiroz, MGR, Toyama, M. H., Fonteles, M. C., Martins, AMC, Monteiro, HSA   +12 more
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Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus ( )

Toxicon, 2016
Potassium (K(+)) channels are trans-membrane proteins, which play a key role in cellular excitability and signal transduction pathways. Scorpion toxins blocking the ion-conducting pore from the external side have been invaluable probes to elucidate the structural, functional, and physio-pathological characteristics of these ion channels.
Marie-France, Martin-Eauclaire, Adriano M C, Pimenta, Pierre E, Bougis, Maria-Elena, De Lima   +3 more
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Novel components of Tityus serrulatus venom: A transcriptomic approach

Toxicon, 2021
Several research groups have studied the components produced by the venom gland of the scorpion Tityus serrulatus, which has one of the most lethal venoms in the world. Various methodologies have been employed to clarify the complex mechanisms of action of these components, especially neurotoxins and enzymes.
Yan, Kalapothakis, Kelton, Miranda, Adriana Heloísa, Pereira, Amanda S A, Witt, Camila, Marani, Ana Paula, Martins, Hortênsia Gomes, Leal, Edimar, Campos-Júnior, Adriano M C, Pimenta, Adolfo, Borges, Carlos, Chávez-Olórtegui, Evanguedes, Kalapothakis   +11 more
openaire   +2 more sources

Tityus serrulatus venom – A lethal cocktail

Toxicon, 2015
Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom is composed of several compounds such as mucus, inorganic salts, lipids, amines, nucleotides, enzymes, kallikrein inhibitor, natriuretic peptide, proteins with high molecular mass, peptides, free amino acids and neurotoxins. Neurotoxins are considered the most
Manuela Berto, Pucca, Felipe Augusto, Cerni, Ernesto Lopes, Pinheiro Junior, Karla de Castro Figueiredo, Bordon, Fernanda Gobbi, Amorim, Francielle Almeida, Cordeiro, Heloisa Tavoni, Longhim, Caroline Marroni, Cremonez, Guilherme Honda, Oliveira, Eliane Candiani, Arantes   +9 more
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Tityus serrulatus Scorpion Venom and Toxins: An Overview

Protein & Peptide Letters, 2009
Tityus serrulatus is considered the most dangerous scorpion in South America and responsible for most of the fatal cases. This review will focus on Tityus serrulatus scorpion venom (Tsv), its long-chain Na(+)-channel toxins (NaTx), which include alpha- and beta-neurotoxins, short-chain K(+)-channel toxins (KTx), hyaluronidase, proteases and other ...
Cologna, Camila T., Marcussi, Silvana, Giglio, Jose R., Soares, Andreimar M., Arantes, Eliane C.   +4 more
openaire   +2 more sources

Enzymes with gelatinolytic activity can be found in Tityus bahiensis and Tityus serrulatus venoms

Toxicon, 2002
Enzymes with gelatinolytic activity were detected in Tityus bahiensis and Tityus serrulatus venom. Their activity was optimal at pH 8.0 in SDS-PAGE-gelatin. They were inhibited by PMSF but not by iodoacetamide, pepstatin or phenantrolin in the assay conditions used. This suggests that these enzymes are serine proteases.
F M, Almeida, A M C, Pimenta, S G, De Figueiredo, M M, Santoro, M F, Martin-Eauclaire, C R, Diniz, M E, De Lima   +6 more
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Effects of Tityus serrulatus scorpion venom on thromboelastogram in rats

Toxicon, 2015
Thromboelastometry was used to evaluate blood coagulation in anesthetized rats after intravenous administration of Tityus serrulatus scorpion venom (Tx). Tracheostomy followed by catheterization of the left jugular vein and right carotid artery were performed for Tx or Ringer's lactate solution injection and blood sample harvesting, respectively. Blood
Thiago A, Lisboa, Marcus Vinícius M, Andrade, João B, Rezende-Neto, Maria Júlia M, Silva, Mário G, Carvalho, Tasso, Moraes-Santos, Daniel D, Ribeiro, José Renan, Cunha-Melo   +7 more
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Venom variability among several Tityus serrulatus specimens

Toxicon, 1997
Individual differences in venom composition among several Tityus serrulatus specimens collected in the same area were examined by enzyme-linked immunosorbent assay (ELISA). Polyclonal antibodies raised against whole venom and against the alpha-type (toxin IV-5 or Ts IV) and the beta-type toxin (toxin gamma or Ts VII) were used to study specific ...
E, Kalapothakis, C, Chávez-Olórtegui
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99mTc labeling of the scorpion (Tityus serrulatus) antivenom

Journal of Radioanalytical and Nuclear Chemistry, 2008
F(ab’)2 is the fragment involved in the immunotherapy for scorpion stings and it would be convenient to label it with 99mTc for organ distribution and pharmacokinetics studies. The aim of the present study was to label scorpion antivenom F(ab’)2 with 99mTc keeping its biological activity, integrity and stability.
D. S. Cardoso, R. J. Rodrigues, V. P. C. P. Toledo, T. Moraes-Santos, V. N. Cardoso, E. A. Nunan   +5 more
openaire   +1 more source

The genomic region encoding toxin gamma from the scorpionTityus serrulatuscontains an intron

FEBS Letters, 1993
The gene encoding toxin gamma from the scorpion, Tityus serrulatus, was amplified by PCR from genomic DNA employing synthetic oligonucleotides designed from the reported cDNA sequence.
Baltazar Becerril, MIGUEL Corona, Brian M Martin   +2 more
exaly   +2 more sources