Results 191 to 200 of about 2,757 (231)

Effects of Tityus serrulatus scorpion venom on thromboelastogram in rats

Toxicon, 2015
Thromboelastometry was used to evaluate blood coagulation in anesthetized rats after intravenous administration of Tityus serrulatus scorpion venom (Tx). Tracheostomy followed by catheterization of the left jugular vein and right carotid artery were performed for Tx or Ringer's lactate solution injection and blood sample harvesting, respectively. Blood
Maria Júlia M. Silva, Marcus V. Andrade, Thiago A. Lisboa, Daniel Dias Ribeiro, José Renan Cunha-Melo, Mário G. Carvalho, Joao B Rezende-Neto, Tasso Moraes-Santos   +7 more
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99mTc labeling of the scorpion (Tityus serrulatus) antivenom

Journal of Radioanalytical and Nuclear Chemistry, 2008
F(ab’)2 is the fragment involved in the immunotherapy for scorpion stings and it would be convenient to label it with 99mTc for organ distribution and pharmacokinetics studies. The aim of the present study was to label scorpion antivenom F(ab’)2 with 99mTc keeping its biological activity, integrity and stability.
Elzíria de Aguiar Nunan, Valbert Nascimento Cardoso, V. P. C. P. Toledo, R. J. Rodrigues, D. S. Cardoso, Tasso Moraes-Santos   +5 more
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A comparative study of pathophysiological alterations in scorpionism induced by Tityus serrulatus and Tityus bahiensis venoms

Toxicon, 2018
Scorpionism is a relevant public health problem in several countries in tropical and subtropical regions. In Brazil, Tityus serrulatus sting can induce acute lung injury in part as a consequence of inflammation. Despite the occurrence of other scorpions of Tityus genus in Brazilian scorpiofauna, the knowledge regarding pulmonary alterations is related ...
Jackson G. Miyamoto, Fabio B. Andrade, Camila R. Ferraz, Denise M. Cândido, Irene Knysak, Émerson J. Venancio, Waldiceu A. Verri, Maristella A. Landgraf, Richardt G. Landgraf, Fábio H. Kwasniewski   +9 more
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Reproductive toxic effects of Tityus serrulatus scorpion venom in rats

Reproductive Toxicology, 2008
Tityus serrulatus is the most venomous scorpion in Brazil. Little is known about the effect of maternal exposure to the venom on fetal development. We investigated the effect of low to moderate doses of the venom (0.3 or 1.0 mg/kg s.c. on either day 5 or day 10 of gestation) on pregnant rats and on their offspring.
Maria Martha Bernardi, Karen Cruttenden, Valquíria Abrão Coronado Dorce, Ana Leonor Abrahão Nencioni   +3 more
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The kinin system in the envenomation caused by the Tityus serrulatus scorpion sting

Toxicology and Applied Pharmacology, 2004
Several lines of evidence in experimental animals indicate that the kinin system may participate in the pathogenesis of envenomation by the Tityus serrulatus (Ts) scorpion sting, but there are no studies in humans with regard to this system. In this study, we evaluated the plasma levels of high-molecular (HKg) and low-molecular (LKg) weight kininogens (
Yara Diniz de Matos Fukuhara, Fernando Q. Cunha, Eduardo Antônio Donadi, Renata Dellalibera-Joviliano, Marina Lemos dos Reis   +4 more
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Lung oedema induced by Tityus serrulatus scorpion venom in the rat

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1997
The effects of drugs were investigated on the induction of acute lung oedema by scorpion Tityus serrulatus venom in male Wistar rats (200-230 g) anaesthetized with sodium pentobarbital (40 mg/kg, i.p.). Intravenous (i.v.) injection of scorpion venom (0.5 mg/kg) into 12 rats induced arterial hypertension and severe lung oedema, whereas i.v. injection of
O.A. Rocha, I.M. De Matos, L. Freire-Maia, Romulo Leite   +3 more
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Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats

Toxicon, 1993
This study was designed to investigate the convulsant effects of T. serrulatus scorpion venom in rats. Pretreatment of rats with venom increased the minimum convulsant dose of picrotoxin, impaired convulsion generalization and displaced to the left the dose-response curve for picrotoxin.
V.A.C. Dorce, M.R.L. Sandoval
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Immune cells recruitment and activation by Tityus serrulatus scorpion venom

Toxicon, 2011
Despite several studies showed that the Tityus serrulatus scorpion venom (Tsv) induces an inflammatory response, just a few have investigated the effect of the venom on the immune response. Therefore, the aim of this study was to evaluate alterations of venom application on lymphoid organs and on the recruitment and activation of cells and also on the ...
Anne Karine Martins Assunção, Márcia C.G. Maciel, Lucilene A. Silva, Flávia R.F. Nascimento, Eder Magalhães Silva Fialho, Rosane N. M. Guerra, Aramys Silva Reis, Thiare S. Fortes, Fábio H. Kwasniewski, Arlley C.B. Silva   +9 more
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Tityus serrulatus venom peptidomics: Assessing venom peptide diversity

Toxicon, 2008
MALDI-TOF-TOF and de novo sequencing were employed to assess the Tityus serrulatus venom peptide diversity. Previous works has shown the cornucopia of molecular masses, ranging from 800 to 3000Da, present in the venom from this and other scorpions species. This work reports the identification/sequencing of several of these peptides. The majority of the
Breno Rates, Márcia Helena Borges, Michael K. Richardson, Adriano Monteiro de Castro Pimenta, Karla K.F. Ferraz, Maria Elena de Lima   +5 more
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Tityus serrulatus Hypotensins: A new family of peptides from scorpion venom

Biochemical and Biophysical Research Communications, 2008
Using a proteomic approach, a new structural family of peptides was put in evidence in the venom of the yellow scorpion Tityus serrulatus. Tityus serrulatus Hypotensins (TsHpt) are random-coiled linear peptides and have a similar bradykinin-potentiating peptide (BPP) amino acid signature.
Verano-Braga, T., Rocha-Resende, C., Silva, D. M., Ianzer, D., Martin-Eauclaire, M. F., Bougis, P. E., de Lima, M. E., Santos, R. A. S., Pimenta, A. M. C.   +8 more
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