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Renal effects and vascular reactivity induced by Tityus serrulatus venom
Toxicon, 2005Tityus serrulatus, popularly known as yellow scorpion, is one of the most studied scorpion species in South America and its venom has supplied some highly active molecules. The effects of T. serrulatus venom upon the renal physiology in human showed increased renal parameters, urea and creatinine.
Alves, R. D. +12 more
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Effect of the venom of the scorpion Tityus serrulatus on adrenal gland catecholamines
Toxicon, 1968Abstract A sublethal dose of the venom of the scorpion Tityus serrulatus produced a depletion of adrenal gland catecholamines. This effect was blocked on denervation of the adrenals. The action of the venom on the chromaffin granules in vitro was not observed. Certain fractions of the venom elicited the same effects as the whole venom.
G. Gazzinelli +3 more
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Ipomoea asarifolia neutralizes inflammation induced by Tityus serrulatus scorpion venom
Journal of Ethnopharmacology, 2014Envenoming caused by scorpion sting is a serious public health problem. In Brazil, 13,038 accidents caused by venomous animals have been reported. Of this total, 53% of the cases and 14 deaths were caused by scorpions. Furthermore, Tityus serrulatus (Buthidae) is the most dangerous scorpion due to the high toxicity of its venom.
Arnóbio Antônio da Silva-Júnior +9 more
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Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting
Toxicon, 1999Seventeen patients stung by Tityus serrulatus scorpion were classified as mild (pain at the site of the sting, n = 6), moderate (local pain and one of the following manifestations: vomiting, psychomotor agitation, prostration, sweating, tachypnea, tachycardia and mild arterial hypertension, n = 10) and severe cases (equal moderate cases plus cardiac ...
Mônica de Mônico Magalhães +8 more
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Purification and partial characterization of a second toxin from the scorpion Tityus serrulatus
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19761. 1. A purification procedure is described for a second toxin of T. serrulatus, which also can be used with advantage for toxin I. 2. 2. Aminoacid compositions of toxins I and II were determined. 3. 3. Molecular weight of the toxins, were 6400 and 7700, respectively for toxins I and II. 4. 4.
David Toledo, Armando G.A. Neves
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Evidence for a direct action of Tityus serrulatus scorpion venom on the cardiac muscle
Toxicon, 2001The ability of toxins to activate the cardiovascular system plays an important role in the morbidity and lethality of the Tityus serrulatus scorpion envenoming. Most of the actions of the scorpion toxins are indirect and due to the release of adrenergic and cholinergic neurotransmitters.
Antônio Lúcio Teixeira +5 more
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Peripheral Effects ofTityus serrulatusScorpion Venom
Journal of Toxicology: Toxin Reviews, 1995AbstractIn this review we describe the peripheral effects induced by Tityus serrulatus scorpion venom and two of the most important toxins-tityustoxin and toxin Ts-γ purified from the crude venom. The complex cardiac arrhythmias elicited by the venom or the toxins were explained by the release of catecholamines and acetylcholine. In isolated rat atria,
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Technetium-99m labeling of tityustoxin and venom from the scorpion Tityus serrulatus
Applied Radiation and Isotopes, 2002The tityustoxin, the most toxic fraction from scorpion Tityus serrulatus venom, has been used as a tool in several neurochemical and neuropharmacological studies. Biological activities of labeled and unlabeled tityustoxin and venom were compared. The samples were labeled in the presence of stannous chloride and sodium borohydride with a yield of 60-70%
Valbert Nascimento Cardoso +2 more
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Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus ( )
Toxicon, 2016Potassium (K(+)) channels are trans-membrane proteins, which play a key role in cellular excitability and signal transduction pathways. Scorpion toxins blocking the ion-conducting pore from the external side have been invaluable probes to elucidate the structural, functional, and physio-pathological characteristics of these ion channels.
Adriano Marçal Pimenta +3 more
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Toxicology Letters, 1994
The acetylcholine (ACh) liberating effect on rat brain slices of tityustoxin, an alpha toxin from the scorpion Tityus serrulatus venom, was measured in the absence and presence of dithiothreitol (DTT). The rate of net ACh liberation by toxin concentrations of 2 nmol in 5 ml of organ bath, was 7.5 +/- 0.09 nmol g-1 min-1. If DTT at a final concentration
Geovanna Novaes +2 more
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The acetylcholine (ACh) liberating effect on rat brain slices of tityustoxin, an alpha toxin from the scorpion Tityus serrulatus venom, was measured in the absence and presence of dithiothreitol (DTT). The rate of net ACh liberation by toxin concentrations of 2 nmol in 5 ml of organ bath, was 7.5 +/- 0.09 nmol g-1 min-1. If DTT at a final concentration
Geovanna Novaes +2 more
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