Results 121 to 130 of about 879 (203)

Androgens Modulate Tumor–Immune Interactions in Testicular Germ Cell Tumors

open access: yesAndrology, EarlyView.
ABSTRACT Background The majority of testicular germ cell tumors (TGCT) are derived from the germ cell neoplasia in situ and arise after puberty in the local presence of high levels of testosterone. The seminoma subtype features a rich inflammatory infiltrate which impacts tumor progression but the role of testosterone in shaping tumor–immune ...
Ida Hamann   +6 more
wiley   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid   +9 more
wiley   +1 more source

Scalable Computation of Topological Abstractions for Scalar Data

open access: yesComputer Graphics Forum, EarlyView.
Abstract Topological data analysis has become an important tool for large scale scalar data analysis and visualization, efficiently extracting the inherent structure and features of interest of the data. However, with growing dataset sizes and complexity, it is increasingly becoming infeasible to compute topological abstractions of interest in serial ...
M. Will   +6 more
wiley   +1 more source

Biological Insights into Intestinal Adaptation from Preclinical Models of Short Bowel Syndrome. [PDF]

open access: yesCells
Pane C   +14 more
europepmc   +1 more source

Integrative transcriptomic and machine learning approaches reveal candidate genes for silk and venom production in Bibionomorpha (Diptera)

open access: yesInsect Molecular Biology, EarlyView.
Multi‐species transcriptomics and deep learning identified candidate genes associated with silk and venom production in Bibionomorpha. Venom‐associated genes were enriched in proteases, inhibitors and pore‐forming proteins, whereas silk‐related genes showed chitin‐binding and peritrophin domains. Integrating co‐expression networks, machine learning and
Daniel Kenji Matuo   +2 more
wiley   +1 more source

Complementary or Substitutive Environmental Governance? ISO 14001 and Environmental Stringency for Emission Reduction

open access: yesJournal of Management Studies, EarlyView.
Abstract In this paper, we adopt the so‐called ‘related’ perspective on business and government relations and propose that they interact and influence one another in governing corporate responsibility. We theorize that private and public governance may operate as complements or substitutes, and conduct a comparative institutional analysis to identify ...
Irene Margaret   +2 more
wiley   +1 more source

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