Results 151 to 160 of about 30,249 (202)

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

Exploring Resistance to ETS Targeting Agents in Diffuse Large B‐Cell Lymphoma

Cancer Medicine, Volume 15, Issue 5, May 2026.
This study provides the first systematic characterization of resistance to ETS inhibition in diffuse large B‐cell lymphoma (DLBCL). Using TK216‐resistant models, we reveal heterogeneous escape mechanisms, including MDR1 upregulation, transcriptional reprogramming, and cytoskeletal remodeling, each associated with distinct mutational signatures ...
Filippo Spriano, Luciano Cascione, Chiara Tarantelli, Giulio Sartori, Alberto J. Arribas, Adriana Velasova, Sara Napoli, Ondrej Havranek, Jeffrey A. Toretsky, Francesco Bertoni   +9 more
wiley   +1 more source

A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity. [PDF]

Cancer Res
Buckenmeyer MJ, Brooks EA, Taylor MS, Orenuga IK, Yang L, Holewinski RJ, Meyer TJ, Galloux M, Garmendia-Cedillos M, Pohida TJ, Andresson T, St Croix B, Wolf MT.   +12 more
europepmc   +1 more source

Direct Mechanoorganocatalysis via Surface Functionalization of Milling Reactors With Amine Functions

ChemistryEurope, Volume 4, Issue 5, May 2026.
Surface functionalization of milling jars in epoxy resin furnished reactive milling jars, able to perform direct mechanoorganocatalysis with high efficiency, recyclability, and simplified purification. This proof of concept was applied successfully to base‐catalyzed Knoevenagel condensation and multicomponent reactions.
Joao Tanepau, Maxime Provost, Marie Gressier, Marie‐Joëlle Menu, Sandrine Duluard, Frédéric Lamaty, Julien Pinaud, Xavier Bantreil   +7 more
wiley   +1 more source

Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles.

Lab Chip
Jing W, Noh H, Tan TJC, Wu NC, Han HS.
europepmc   +1 more source

Threshold effect study on the development of prefabricated buildings for energy conservation and emission reduction in the construction industry. [PDF]

Sci Rep
Qi Y, He X, Li Y, Jia Y.
europepmc   +1 more source

A 25‐Year Bibliometric and Scientometric Analysis of Facial Paralysis Rehabilitation: Knowledge Structure, Influential Works, and Emerging Research Frontiers (2000–2025)

Microsurgery, Volume 46, Issue 4, May 2026.
ABSTRACT Background Facial paralysis rehabilitation has progressed substantially over the past two decades, yet the scientific landscape of this field remains highly fragmented across surgical, neurological, and rehabilitation disciplines. Despite growing clinical and technological advances—including neuromuscular retraining, chemodenervation ...
Mert Doğan, Fatma Ayvat
wiley   +1 more source

Knowledge-Graph-Driven Fault Diagnosis Methods for Intelligent Production Lines. [PDF]

Sensors (Basel)
Chen Y, Zhou M, Zhang M, Zha M.
europepmc   +1 more source

A Blockchain‐Less Traceability System for Agriculture Using DAG, IPFS, and Serverless Deployments

International Journal of Network Management, Volume 36, Issue 3, May/June 2026.
ABSTRACT Ensuring transparency and integrity in agricultural data management is a critical challenge as the sector increasingly relies on advanced technologies. The primary problem is maintaining data traceability and security throughout the supply chain.
Antonio Villafranca, Igor Tasic, Victor Gallegos, Almudena Gimenez, Jesus Ochoa Rego, Juan Antonio Fernandez, Maria‐Dolores Cano   +6 more
wiley   +1 more source

Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and mitochondria in excitatory neurons. [PDF]

Mol Neurodegener Adv
Espinosa-Garcia C, Srivastava U, Kumar P, Kour D, Malepati S, Tobin BR, Xiao H, Sunna S, Bowen CA, Cheng L, Bagchi P, Duong DM, Whitworth TJ, Liu X, Seyfried NT, Wood LB, Faundez V, Rangaraju S.   +17 more
europepmc   +1 more source