Results 161 to 170 of about 281,886 (289)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Pembelajaran Gerak Dan Lagu Di TK Dharma Wiweka Kelurahan Pedungan Kecamatan Denpasar Selatan

, 2018
Penelitian ini membahas tentang Pembelajaran Gerak Dan Lagu TK Dharma Wiweka Kelurahan Pedungan Kecamatan Denpasar Selatan, diberikan untuk membantu meletakkan dasar kearah perkembangan sikap, pengetahuan, keterampilan, dan daya cipta yang diperlukan ...
Ni Ketut, Yuliasih, Pande Kadek, Widiastini Putri, NI Wayan, Mudiasih   +2 more
core   +1 more source

Molecular cloning of a monkeypox virus clade IIb genome and construction of an attenuated mutant for basic and translational research. [PDF]

Emerg Microbes Infect
Klatt V, Meyer Zu Natrup C, Staliunaite L, Clever S, Knickmann J, Ohrnberger S, Seib J, Ostermann E, Weichel HM, Addo MM, Volz A, Brune W.   +11 more
europepmc   +1 more source

Rainfall Shapes the Diversity of Soil Nitrogen‐Fixing Microorganisms Worldwide

Advanced Science, EarlyView.
This study reveals the distinctive pattern and mechanism of rainfall driving the global biodiversity and biogeography of soil potential N‐fixing microorganisms, and constructs the theoretical framework. The results guide us on how to maintain ecosystem productivity under future climate changes (e.g., whether a specific region needs more N fertilizers ...
Bin Hua, Shuang Pang, Ang Li, Zonghao Hu, Honghui Wu, Shuhan Zhang, Yi Fan, Yi Wu, Wei Yang, Yachao Zhao, Yupeng Guan, Baoming Ji, Deliang Kong, Yong Zhao, Anton A. Goncharov, Anastasia Yu. Korotkevich, Rong Mao, Yang Zhang, Ximei Zhang   +18 more
wiley   +1 more source

Multifunctional biohybrid nanoplatform interferes electron transport chain amplifying mitochondrial metabolism-mediated anti-tumor therapy. [PDF]

Mater Today Bio
Meng T, Gao T, Yu N, Guo J, Zuo W, Chen J, Yang J.   +6 more
europepmc   +1 more source

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

TPGS Analog-Mediated Intracellular ROS-Amplifying Strategy Potentiates the In Vitro Anticancer Activity of a Dual-Thioketal-Linked Polymeric Drug Conjugate in A549 Lung Cancer Cells. [PDF]

Pharmaceutics
Kim HC, Lee KM, Hwang YJ, Lee J, Han HS.
europepmc   +1 more source

TK Bro

, 2009
Banverkets publikationsbeteckning BVS 1583.10.TK Bro är en teknisk beskrivning som anger Vägverkets och Banverkets krav vid nybyggande och förbättring av broar och vissa andra i TK Bro specificerade byggnadsverk. Ersätter ATB Bro 2004. Ersätts av Trafikverkets publikation 2011:085, TRVK Bro 11.Förtydliganden och tillägg till publikationen finns på ...
openaire   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Mesleki Toplantılar [PDF]

, 2004
TK YAYIN KURULU, YAYIN KURULU, TK, TK Yayın Kurulu, Kurulu, TK Yayın, Yayın Kurulu, TK   +4 more
core   +1 more source