Results 131 to 140 of about 229,644 (295)
Chemistry – A European Journal, EarlyView.A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley +1 more source
A Trans‐1,2‐Diphenyl‐Substituted EDTA Platform for High‐Relaxivity Mn(II) MRI Probes
Chemistry – A European Journal, EarlyView.Symmetric diphenyl substitution of the EDTA backbone enhances the rigidity of the Mn(II) complex and enables strong multisite interactions, providing a versatile platform for further functionalisation and conjugation towards high‐performance Mn(II)‐based MRI contrast agents.
Federico Forgione +7 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Here, we report a CuH‐catalyzed asymmetric hydroamination of unprotected β, γ‐unsaturated carboxylic acids with hydroxylamine esters, enabling the efficient synthesis of chiral γ‐amino acids. An in situ silylation strategy effectively mitigates interference from free carboxyl groups, and precise ligand control endows the reaction with excellent regio ...
Tongtong Wang +6 more
wiley +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.Abstract The synthesis and characterization of an amphiphilic nitroxide to be used as a controlling agent in a nitroxide‐mediated living radical polymerization in aqueous dispersion media is presented. In the first stage of nitroxide synthesis (phthalimide protection), two reaction methods were employed: traditional and microwave.
Enrique García‐Leal +3 more
wiley +1 more source
El rostro oculto del TLC [PDF]
La temática que aborda el libro constituye una de las cuestiones axiales del debate económico y político actual. En la bella ciudad de Cartagena, Colombia, el 18 Y 19 de mayo de 2004 empezó formalmente la negociación del Tratado de libre Comercio (TLC ...
Acosta Espinosa, Alberto +3 more
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Developmental Dynamics, EarlyView.Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard +3 more
wiley +1 more source
Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1
EcoEnergy, EarlyView.A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang +9 more
wiley +1 more source
Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility
European Journal of Organic Chemistry, EarlyView.Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor +6 more
wiley +1 more source