Results 191 to 200 of about 332,408 (303)
ABSTRACT Background An understanding of the nature of long Covid (LC) is evolving, with recent evidence highlighting the role of increased sympathetic activation and decreased parasympathetic response. Building upon this emerging science, the ‘Transforming Long COVID’ (TLC) programme was developed to support participants in their recovery by (i ...
Sarahjane Belton +5 more
wiley +1 more source
A Retrospective Observational Study of Pulmonary Impairments in Long COVID Patients. [PDF]
Daodu LP +4 more
europepmc +1 more source
In our study, we obtained both non‐covalent and covalent PLpro inhibitors. Additionally, the stable protein‐ligand interactions of the active compound were examined using advanced computational docking and molecular dynamics simulations. The non‐covalent inhibitor 2t showed antiviral activity with an EC50 of 2.89 µM, indicating its potential as a ...
Elena‐Oriana Iuga +11 more
wiley +1 more source
Formal Synthesis of Ortho-Cyanated N-Heterocycles via Direct, Metal-Free Cyanation of N-Oxides Under Benign Conditions. [PDF]
Xiao H, Wufuer R, Wang D.
europepmc +1 more source
Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira +7 more
wiley +1 more source
Functional respiratory imaging reveals early structural and functional airway responses to benralizumab in severe eosinophilic asthma. [PDF]
Conemans L +5 more
europepmc +1 more source
Batch and flow electrochemical methods enable direct C‐7 oxidation of abietic and dehydroabietic acids from colophony or their methyl derivatives to the corresponding ketones, while a mediated protocol enables additional C‐15 oxygenation, providing sustainable and selective routes to diversified abietane derivatives.
Inês S. Martins +2 more
wiley +1 more source
Rapid Chromatographic and Spectroscopic Analysis of Extracted Raw Propolis. [PDF]
Cvetković D +3 more
europepmc +1 more source
A highly stereoselective desymmetrization of pseudo‐para diformyl[2.2]paracyclophanes is developed via chiral Brønsted acid‐catalyzed reductive amination. This protocol provides efficient access to enantiopure planar chiral paracyclophanes with broad substrate scope, excellent enantioselectivity, and versatile postsynthetic functionalization. Access to
Sandip Baban Shinde +4 more
wiley +1 more source

