Advanced Science, Volume 13, Issue 25, 4 May 2026.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Green evaluation of human plasma levels of metformin, linagliptin, and empagliflozin using HPLC and HPTLC methods: a pharmacokinetic study. [PDF]
BMC ChemSattar OIA +4 more
europepmc +1 more source
One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu +8 more
wiley +1 more source
β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors. [PDF]
ChembiochemSjövall F, Nilsson UJ.
europepmc +1 more source
Model‐Inversion‐Resistant Physical Unclonable Neural Network Using Vertical NAND Flash Memory
Advanced Science, Volume 13, Issue 25, 4 May 2026.Schematic and key features of the proposed forward‐forward physical unclonable neural network (FF‐PUNN), incorporating a concealable physical unclonable function (PUF) layer and forward‐forward (FF) learning. ABSTRACT The growing use of neural networks in privacy‐sensitive applications necessitates architectures that inherently protect both data and ...
Sung‐Ho Park +8 more
wiley +1 more source
Development of a radio thin-layer chromatography scanner: Design and qualification. [PDF]
EJNMMI Radiopharm ChemChivato Martín-Falquina T +3 more
europepmc +1 more source
Pulmonary hypertension associated with COPD: exploring the complex spectrum of an unmet clinical challenge. [PDF]
ERJ Open ResRiou M, Beurnier A, Montani D.
europepmc +1 more source
Physicochemical and Mechanical Characterization of Commercial Collagen‐Based Wound Dressings
Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.Commercial collagen‐based wound dressings are systematically compared to reveal how porous architecture governs hydration‐driven swelling and mechanical adaptation. Distinct structure–function relationships are identified, showing that wet‐state elasticity and conformability emerge from material composition and processing rather than manufacturer ...
Davide V. Verdolino +4 more
wiley +1 more source
Labeling of Amine-Modified Material Surfaces with PFB-Fluorescein. [PDF]
Nanotechnol Sci ApplJaskot K +10 more
europepmc +1 more source
Fluorometric Detection of Sarin Vapor Using Fluorene and Fluorenone Derivatives
Analysis &Sensing, Volume 6, Issue 3, May 2026.In this study, we present the detection of the actual nerve agent sarin in the gas phase, assessing more than twenty fluorene and fluorenone derivatives as organic fluorescent probes. One molecule in particular showed very promising results in terms of stability and selectivity.
Valentin A. Bureau +4 more
wiley +1 more source