Results 31 to 40 of about 143,294 (307)
Language and Imagination: Evolutionary explorations
, 2017 This article provides a functional analysis of the conditions for language to emerge, and analyzes its rolein imagination. It starts with some initial reflections on imagination and its evolutionary beginnings in relation to the role of working memory ...
Emeriti TLC +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
EnergiesIn this study, a double-input single-output bidirectional DC–DC converter is considered. This particular architecture allows less switches to be used than a conventional solution.
Alessandro Benevieri +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
El TLC Colombia-Japón: ¿oportunidad comercial? Un análisis ex-ante
Revista Finanzas y Política Económica, 2019 El presente artículo investiga los efectos cuantitativos de una reducción arancelaria entre Colombia y Japón como consecuencia de un posible acuerdo comercial. Utilizando algunos indicadores de dinamismo comercial y un modelo de equilibrio parcial basado
Stella Venegas Calle +1 more
doaj +1 more source
Impacto del TLC en Bogotá-Cundinamarca. Servicios de software [PDF]
, 2007 Este informe sobre el impacto del TLC en Bogotá-Cundinamarca Servicios de software incluye el rezago frente a la globalización, el impacto del TLC en la economía regional y el TLC y la cadena de servicios de software.Gestión del ...
Fedesarrollo
core
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson +5 more
wiley +2 more sources
The Telencephalon Saved by TLC [PDF]
Neuron, 2002 The telencephalon is one of the most complex parts of the brain, and its patterning is still poorly understood. In this issue of Neuron, describe a novel Wnt antagonist Tlc, a member of the secreted Frizzled-related protein (sFrp) family. Secreted from the anterior boundary of the zebrafish neural plate, Tlc appears to protect the telencephalon from ...
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He +9 more
wiley +1 more source