Results 31 to 40 of about 25,058 (147)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Association Between Hepatic Steatosis and Deterioration of Metabolic Health in Obese Individuals: A 12‐Year Follow‐Up of the Tehran Lipid and Glucose Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
This 12‐year study reveals that hepatic steatosis significantly predicts the transition from metabolically healthy obesity (MHO) to an unhealthy phenotype in obese individuals, underscoring the clinical importance of early detection and intervention to prevent metabolic deterioration.
Behnaz Abiri, Mohammad Nikoohemmat, Maryam Mahdavi, Amirhossein Ramezani Ahmadi, Majid Valizadeh, Fereidoun Azizi, Farhad Hosseinpanah   +6 more
wiley   +1 more source

Importance of far-infrared mapping in a spiral galaxy: AKARI observation of M81

, 2010
The importance of the far-infrared (FIR) mapping is demonstrated for a face-on spiral galaxy, M81, by analyzing its imaging data at 65, 90, and 140 {\mu}m taken by AKARI.
Aannestad, Ai-Lei Sun, Baggett, Bendo, Braun, Buat, Cheng, Dale, Dale, Draine, Draine, Draine, Freedman, Harper, Hibi, Hirashita, Hirashita, Hirashita, Hiroyuki Hirashita, Inoue, Kawada, Kennicutt, Li, Lowe, Mathis, Mathis, Murakami, Nagata, Pilbratt, Poglitsch, Pollo, Pérez-González, Reach, Rice, Rots, Sauvage, Shibai, Shirahata, Suzuki, Suzuki, Takeuchi, Walterbos, Weingartner, Yamamura   +43 more
core   +1 more source

Relationship Between Body Composition With Carotid Intima Media Thickness in Young Adults: Tehran Lipid and Glucose Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
Our study of 795 young adults found that higher skeletal muscle mass was linked to thicker carotid arteries (increased cIMT), even after considering body fat and other risks. The takeaway: in early adulthood, higher muscle mass—often paired with higher body fat—may signal early vascular changes rather than protection.
Mohammad Nikoohemmat, Behnaz Abiri, Majid Valizadeh, Maryam Mahdavi, Pooneh Dehghan, Fereidoun Azizi, Farhad Hosseinpanah   +6 more
wiley   +1 more source

On the Hybrid Minimum Principle On Lie Groups and the Exponential Gradient HMP Algorithm [PDF]

, 2014
This paper provides a geometrical derivation of the Hybrid Minimum Principle (HMP) for autonomous hybrid systems whose state manifolds constitute Lie groups $(G,\star)$ which are left invariant under the controlled dynamics of the system, and whose ...
E. Caines, Farzin Taringoo, Peter
core  

A voxel‐wise uncertainty‐guided framework for glioma segmentation using spherical projection‐based U‐Net and localized refinement

Medical Physics, Volume 53, Issue 3, March 2026.
Abstract Background Accurate segmentation of glioma subregions from multi‐parametric MRI (MP‐MRI) is critical for clinical management but remains challenging due to tumor heterogeneity and ambiguous tissue boundaries. Purpose This study proposes an uncertainty‐guided hybrid segmentation framework that integrates spherical projection‐based 2D modeling ...
Zhenyu Yang, Chen Yang, Rihui Zhang, Chunhao Wang, Minbin Chen, Fang‐Fang Yin   +5 more
wiley   +1 more source

Quantum transport in double-gated graphene devices

, 2012
Double-gated graphene devices provide an important platform for understanding electrical and optical properties of graphene. Here we present transport measurements of single layer, bilayer and trilayer graphene devices with suspended top gates.
Abanin, Aoki, Avetisyan, Avetisyan, Bao, C.N. Lau, Castro, Castro, Castro Neto, Cheianov, Craciun, Das Sarma, Dean, Deshpande, Ezawa, Ferrari, Fuhrer, G. Liu, Geim, Gorbachev, Guinea, Guinea, Henriksen, J. Velasco, Jing, Jung, Katsnelson, Katsnelson, Kuzmenko, L. Jing, Lemonik, Liu, Lui, Lui, Mak, Mak, Martin, Martin, McCann, McCann, McClure, Min, Moser, Nandkishore, Nilsson, Novoselov, Novoselov, Novoselov, Oostinga, Ozyilmaz, Partoens, Ponomarenko, Shytov, Stander, Taychatanapat, Taychatanapat, Vafek, Velasco, Velasco, Velasco, W. Bao, Wehling, Weitz, Williams, Xia, Y. Lee, Yan, Young, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zou   +74 more
core   +1 more source

Hydrogravimetry Enables Quantification of Alpine Groundwater Dynamics

Geophysical Research Letters, Volume 53, Issue 3, 16 February 2026.
Abstract Groundwater plays a critical role in the functioning of alpine hydrological systems, and its importance is expected to increase under climate change. However, quantification of groundwater processes in these systems remains highly uncertain. Terrestrial time‐lapse gravimetry (TLG) is a geophysical and geodetic technique whose measured variable
Landon J. S. Halloran, Antoine Carron, Nazanin Mohammadi, Ronny Figueroa, Marie Arnoux   +4 more
wiley   +1 more source

Public Debt Frontiers: The Greek Case [PDF]

, 2017
This paper attempts to quantify the maximum amount of debt that a government can sustain by itself, i.e., the limits to public indebtedness. Using a Dynamic General Equilibrium model where the government is fully characterized, we compute the steady ...
Fernández-de-Córdoba-Martos, Gonzalo, Torres-Chacon, Jose Luis   +1 more
core  

Programming and Reasoning with Guarded Recursion for Coinductive Types

, 2015
We present the guarded lambda-calculus, an extension of the simply typed lambda-calculus with guarded recursive and coinductive types. The use of guarded recursive types ensures the productivity of well-typed programs.
Birkedal, Lars, Bizjak, Aleš, Clouston, Ranald, Grathwohl, Hans Bugge   +3 more
core   +1 more source