Results 1 to 10 of about 123,719 (240)

Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance. [PDF]

PLoS ONE
Development of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species. The uniquely expanded C.
James O'Connor-Moneley, Jessica Fletcher, Cody Bean, Josie Parker, Steven L Kelly, Gary P Moran, Derek J Sullivan   +6 more
doaj   +3 more sources

Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp. [PDF]

PLoS Genetics, 2016
Filamentous growth is a hallmark of C. albicans pathogenicity compared to less-virulent ascomycetes. A multitude of transcription factors regulate filamentous growth in response to specific environmental cues. Our work, however, suggests the evolutionary
Zhongle Liu, Gary P Moran, Derek J Sullivan, Donna M MacCallum, Lawrence C Myers   +4 more
doaj   +3 more sources

Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in α-, β- and γ- TLO gene function. [PDF]

PLoS Genetics, 2023
The Candida albicans genome contains between ten and fifteen distinct TLO genes that all encode a Med2 subunit of Mediator. In order to investigate the biological role of Med2/Tlo in C.
Jessica Fletcher, James O'Connor-Moneley, Dean Frawley, Peter R Flanagan, Leenah Alaalm, Pilar Menendez-Manjon, Samuel Vega Estevez, Shane Hendricks, Andrew L Woodruff, Alessia Buscaino, Matthew Z Anderson, Derek J Sullivan, Gary P Moran   +12 more
doaj   +2 more sources

Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits. [PDF]

PLoS Genetics, 2014
The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C.
John Haran, Hannah Boyle, Karsten Hokamp, Tim Yeomans, Zhongle Liu, Michael Church, Alastair B Fleming, Matthew Z Anderson, Judith Berman, Lawrence C Myers, Derek J Sullivan, Gary P Moran   +11 more
doaj   +3 more sources

High efficacy therapy to prevent the formation of meningeal tertiary lymphoid organs after CXCL13 index screening in early multiple sclerosis [PDF]

Frontiers in Neuroscience
Postmortem studies have shown the presence of subpial inflammation with tertiary lymphoid organs (TLO) in the meninges of patients with progressive multiple sclerosis, playing an important role in the pathophysiology of the disease.
Ana C. Londoño, Ana C. Londoño, Carlos A. Mora   +2 more
doaj   +2 more sources

Fluconazole resistance and CDR1 expression in Candida albicans mediated by the hyperactive Tac1-5 transcriptional activator requires Tlo proteins [PDF]

Microbiology (Reading)
Lim W, Lee B, Farrington Z, Abu Alhaija A, Fleming A, Sullivan D, Moran G.   +6 more
europepmc   +2 more sources

TLO

Kobunshi, 2000
佐枝 繁
openaire   +3 more sources

Utjecaj kulture smreke na tlo

Radovi, 2007
Istra`ivanja su provedena s ciljem analize utjecaja smrekovih kultura na tlo. U podru~ju prirodnih sastojina hrasta lu`njaka u sredi{njoj Hrvatskoj (zajednice Carpino betuli-Quercetum roboris /Ani}1959/ Rau{ 1969, subass. typicum i fagetosum) odabrane su tri kulture obi~ne smreke stare 36 – 40 god.
Perković, Ivan, Pernar, Nikola, Vrbek, Boris, Bakšić, Damir, Pilaš, Ivan, Presečan, Milan   +5 more
openaire   +3 more sources

Problem procjeđivanja vode kroz tlo [PDF]

, 2017
Procjeđivanje vode kroz poroznu sredinu česta je pojava koja se događa pri podzemnom tečenju, curenju i infiltraciji, odvodnjavanju mulja u industriji, pročišćavanju industrijske vode, odvodnji i pročišćavanju vode. U svim slučajevima protok je proporcionalan padu tlaka (prikladno izmjerenom i opisanom kao visinska razlika), opisan je Darcy-jevim ...
Luka Andričević
openaire   +2 more sources