Results 181 to 190 of about 169,533 (318)

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Tertiary lymphoid structures guided opportunities and challenges for immunotherapy in early gastroesophageal junction cancer and low rectal cancer. [PDF]

Hum Vaccin Immunother
Zou Q, Zhang Y, Xian Z, Fang Z, Zhang J, Shang L, Wang H, Hu B, Chen Z.   +8 more
europepmc   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

TLS-grapevine2024: A terrestrial laser scanner point cloud dataset of grapevines at different phenological stages. [PDF]

Data Brief
Ferreira L, Marques P, Portela F, Sousa JJ, Peres E, Morais R, Pádua L.   +6 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy. [PDF]

Front Immunol
Li Z, Ruan S, Yu Y, Xiang H, Mi W.
europepmc   +1 more source

Evaluation of Two-Dimensional DBH Estimation Algorithms Using TLS

Jorge Luis Compeán-Aguirre, Pablito Marcelo López‐Serrano, José Luis Silván-Cárdenas, Ciro Andrés Martínez-García-Moreno, Daniel José Vega-Nieva, José Javier Corral‐Rivas, Marín Pompa-García   +6 more
openalex   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Multiomics study on the tertiary lymphatic structure signature of colon cancer. [PDF]

Transl Cancer Res
Wang J, Sun Y, Guo Y, Ren Y, Tu X, Zhang L.   +5 more
europepmc   +1 more source

Automatic detection of color markings and numbers on trees in point clouds from Personal Laser Scanning (PLS) and Terrestrial Laser Scanning (TLS)

Sarah Wagner, Alessa Angerschmid, Anna Saranti, Christoph Gollob, Tim Ritter, Ralf Kraßnitzer, Andreas Tockner, Sarah Witzmann, Andreas Holzinger, Karl Stampfer, Arne Nothdurft   +10 more
openalex   +1 more source