Results 221 to 230 of about 60,981 (309)

Research trends and collaboration patterns in robotic retroperitoneal lymph node dissection for testicular cancer. [PDF]

J Robot Surg
Demir DÖ, Öktem Ç, Gökkurt Y, Bayraktar AB, Varan A.   +4 more
europepmc   +1 more source

Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers

British Journal of Clinical Pharmacology, EarlyView.
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics (CPT) exams, comparing their results to medical students and exploring their ability to identify poorly formulated
Alexandre O. Gérard, Diane Merino, Marc Labriffe, Fanny Rocher, Delphine Viard, Laurence Zemori, Thibaud Lavrut, Erik M. Donker, Joost D. Piët, Jean‐Paul Fournier, Milou‐Daniel Drici, Alexandre Destere   +11 more
wiley   +1 more source

Outcomes of critically ill patients with newly diagnosed Burkitt's lymphoma: a monocentric retrospective study. [PDF]

Ann Intensive Care
Cammarota F, Degoutte C, Calvet L, Chean D, Fieschi C, Thieblemont C, De Pascale G, Darmon M, Zafrani L, Antonelli M, Azoulay E, Dupont T.   +11 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Development and Validation of a New Scoring System (Total Leishmania Score) for Dogs with <i>Leishmania infantum</i> Infection Including Clinical and Laboratory Parameters. [PDF]

Pathogens
Voelk JC, Kaempfle M, Dorsch R, Geisen V, Mueller RS, Lauer SK, Zablotski Y, Hartmann K, Bergmann M.   +8 more
europepmc   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Dissecting the Tumor Microenvironment to Identify Biomarkers of Outcome to Anti-PD-1 Therapy in Clear Cell Renal Cell Carcinoma: analyses of the HCRN GU16-260 trial. [PDF]

Clin Cancer Res
El Ahmar N, Paul MA, Simsek B, Matar S, Jegede OA, Laimon YN, Savla V, Mohanna R, de Oliveira GR, Bagheri Sheshdeh A, Denize T, West DJ, Seager MD, Sun M, Choueiri TK, Xie W, Freeman GJ, Sharpe AH, Braun DA, Haas NB, Hammers H, Bilen MA, Stein M, Sosman JA, Wu CJ, McDermott DF, Atkins MB, Signoretti S.   +27 more
europepmc   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

AI-driven spatial analysis of tumor-infiltrating lymphocytes predicts chemo-immunotherapy response in triple-negative breast cancer. [PDF]

Front Immunol
Liang H, Zhu H, Wang L, Yu J, Feng R, Yan X, Shi L, Xiao J, Zhou H, Chen P, Liu H, Zheng L.   +11 more
europepmc   +1 more source