Results 221 to 230 of about 165,935 (290)

Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the genetic code to scalable and rapid protein production. The recently developed Pichia pastoris CFPS combines advantages of both prokaryotic and eukaryotic systems, including a rapid growth rate ...
Rui Wu, Igor Koop, Gavin Murugan, Thagshanen Thillairajah, Karen M. Polizzi   +4 more
wiley   +1 more source

Organized immunity in the CNS: what stroke reveals about neuroinflammation and lymphoid niches. [PDF]

J Clin Invest
Lee-Chang C.
europepmc   +1 more source

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo, Nagamani Vunnam, Jonathan N. Sachs, Benjamin J. Hackel   +3 more
wiley   +1 more source

The Emerging Role of B Cells and Tertiary Lymphoid Structures in Bladder Cancer. [PDF]

Curr Urol Rep
Penunuri A, Greenberg E, Phillips J, Katims AB.   +3 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

The CXCL13 hub in obesity-related metabolic inflammation: regulation of spatiotemporal heterogeneity and targeted strategies. [PDF]

J Endocrinol
Huang M, Chen X, Jiang Y, Liu T.
europepmc   +1 more source

Combining spatial and single-cell transcriptome data to analyze tertiary lymphoid structures in clear cell renal cell carcinoma reveals prognostic biomarkers. [PDF]

J Transl Med
Li X, Liu P, Li M, Zhou Y, Li T, Yang T, Dong J, Fu C, Zhu Y, Chen L, Ma J, Liu W.   +11 more
europepmc   +1 more source

A Grading System of Intratumoral Tertiary Lymphoid Structure for Combined Hepatocellular-Cholangiocarcinoma: A Multicenter Pathological Study. [PDF]

J Hepatocell Carcinoma
Wang H, Qian YW, Zhao Y, Sheng X, Xia CY, Chen HZ, Cong WM, He MX, Dong H.   +8 more
europepmc   +1 more source

High endothelial venules abundance in tertiary lymphoid structures: a prognostic biomarker in non-small cell lung cancer with neoadjuvant immunochemotherapy. [PDF]

BMC Cancer
Zhang Y, Xie M, Gao J, Ma X, Yao J, Lin X, Bao X, Zhang X, Li K, Du A, Wei B, Zang X, Xue X.   +12 more
europepmc   +1 more source