Results 231 to 240 of about 135,945 (298)

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Toward an Iterative, Testable Transcranial Magnetic Stimulation Framework for Posttraumatic Stress Disorder. [PDF]

Biol Psychiatry Glob Open Sci
Philip NS, van Rooij SJH.
europepmc   +1 more source

High‐Performance Piezoresistive Sensors via Pd/Sn‐Free Graphene‐Catalyzed Metallization of Thermally Repairable Microfiber Scaffolds

Advanced Science, EarlyView.
The multilayer fiber‐based PGC sensor, fabricated via graphene‐mediated electroless copper deposition, demonstrates high sensitivity, mechanical durability, and fast response speed. Additionally, it features low‐temperature thermal assisted recovery and thermal resistance, providing a promising platform for wearable electronic devices and IoT ...
ByungJun Kim, Su Bin Choi, Yeonwook Jeong, Jeong‐Won Yoon, Seung‐Boo Jung, Jong‐Woong Kim   +5 more
wiley   +1 more source

Silver-Initiated C-H/N-H Cross-Coupling of Azines and Their N‑Oxides with Alkylamines. [PDF]

ACS Omega
Kazakova ED, Utepova IA, Musikhina AA, Kiskin MA, Chereneva VD, Sarapultsev AP, Kolonskova ON, Yusupova AR, Borisevich SS, Kholin KV, Budnikova YH, Chupakhin ON, Charushin VN.   +12 more
europepmc   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Self‐Healing UPy‐Functionalized Polyethylene Networks: A Robust Platform for Resilient and High‐Performance Lithium Battery Separators

Advanced Science, EarlyView.
Self‐healing separators are developed by grafting ureidopyrimidinone (UPy) quadruple hydrogen‐bonding motifs onto PE‐HEMA copolymers, blended with high‐MW PEO via solvent‐free hot‐pressing. The dynamic UPy network enables autonomous healing, restoring functionality after short circuits.
Daniele Callegari, Arkadiusz Zych, Roberta Pinalli, Enrico Dalcanale, Eliana Quartarone   +4 more
wiley   +1 more source

Fear learning-induced brain dynamics predict individual extinction memory expression following transcranial magnetic stimulation. [PDF]

Nat Commun
Zhang K, Cui L, Moallem BI, Meelad H, Atiyah Z, Badarnee M, Mason I, Wen Z, George MS, Milad MR.   +9 more
europepmc   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Micropropagation of the Endemic <i>Stachys pinardii</i> Boiss. and Comparative Investigation of the Phytochemical Composition of Cultured and Wild-Grown Plants. [PDF]

Molecules
Üstüner H.
europepmc   +1 more source