Results 241 to 250 of about 291,055 (303)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Tumefactive Multiple Sclerosis Mimicking an Intracranial Mass in a 34-Year-Old Man: A Case Report. [PDF]

Cureus
Al Hassani Z, Darwish R, Al Samirraie B, Aal Yaseen M, Said A.   +4 more
europepmc   +1 more source

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Tianhua mutton sheep. [PDF]

BMC Genomics
Jiang B, Zeng J, Chi H, Shan J, Zhang X, Feng Q, Li F, Yue X, Fu W.   +8 more
europepmc   +1 more source

Efficient Gaussian process-based motor hotspot hunting with concurrent optimization of TMS coil location and orientation. [PDF]

PLoS Comput Biol
Schultheiss DL, Turi Z, Boedecker J, Vlachos A.   +3 more
europepmc   +1 more source

Optimization, implementation, and performance of TMS coils with maximum focality and various stimulation depths. [PDF]

J Neural Eng
Gomez LJ, Murphy DLK, Koponen LM, Hamdan R, Li Y, Wood E, Golden J, Bukhari-Parlakturk N, Goetz SM, Peterchev AV.   +9 more
europepmc   +1 more source

Unveiling Copper-Induced Phase Transitions and Degradation Mechanisms of Transition Metal Sulfide Anodes for Sodium-Ion Batteries. [PDF]

Adv Sci (Weinh)
Choe J, Hur J, Park S, Kim J, Joo J, Park JY, Lee CW, Yuk JM.   +7 more
europepmc   +1 more source

Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder: From Bench to Bedside-A Scoping Review of Neurobiological Mechanisms and Clinical Translation. [PDF]

Bioengineering (Basel)
Trandafir DM, Zamfirache F, Dumitru C, Radu BM, Ciobanu AM.   +4 more
europepmc   +1 more source

Pulse waveform and current direction alter network-level TMS-induced functional connectivity: Evidence from TMS-EEG.

Neuroimage
Lucarelli D, Guidali G, Guidotti R, Pieramico G, Bolognini N, Romani GL, Pizzella V, Marzetti L.   +7 more
europepmc   +1 more source

Evaluation of Variables Influencing Orbital Implant Motility

Soliman NM, Bell S, Gopal BP, Sia DI, Stacey AW, Carpenter D, Sagoo MS.   +6 more
europepmc   +1 more source