Results 101 to 110 of about 26,628 (256)

Open and closed state of the N-lobe. Time dependence of TnC hydrophobic pocket opening distance (d).

, 2013
A, B The TnC N-lobe is shown in red in the Ca2+ saturated, open state; and in blue in the Ca2+ depleted, closed state. Panel A shows the N-lobe viewed from the side, panel B shows the N-lobe viewed from the C-lobe.
Georgi Z. Genchev (390239), Tomoyoshi Kobayashi (390240), Hui Lu (12370)   +2 more
core   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Sustainable Development and Green Modernization as Conditions for the Transition to a New Industrial Revolution

Мир новой экономики, 2018
The article clarifies the contents of such phenomena as the development of “sustainable (green) industry”, “sustainable (green) energy”. Reveals their place in the unfolding processes of the fourth industrial revolution.
S. N. Silvestrov, Yu. V. Zinchenko
doaj  

A Transgenic Rat Model of DXd ADC‐Related Interstitial Pneumonitis for Mechanistic and Translational Research

Cancer Science, EarlyView.
hTROP2 Tg rats exhibit key pathological and transcriptomic features of DXd ADC‐related ILD, supporting their utility as a translational model. Rat, alveolus, antibody illustrations were adapted from NIAID NIH BioArt Source. ABSTRACT Deruxtecan‐based antibody‐drug conjugates (DXd ADCs) provide substantial clinical benefit across multiple malignancies ...
Kazuyoshi Kumagai, Yuma Nagai, Yuji Shirai, Kazunori Fujimoto, Masako Imaoka, Katsuyoshi Chiba   +5 more
wiley   +1 more source

Tenascin-C orchestrates radiotherapy-induced head and neck tumor regression

EMBO Molecular Medicine
Given that head and neck squamous cell carcinoma (HNSCC) patients have poor survival outcomes, a better understanding of the therapeutic benefits of ionizing irradiation (IR), the major treatment modality besides surgery, is needed.
Thomas Loustau, Ioanna Mitrentsi, Nuohan Wang, Caroline Spenlé, Alexia Pavlidaki, Thibaud Tranchant, Gilles Riegel, Akhil Venu, Rime Oueidat, Manuel Koch, Marion Dumas, Fanny Wack, Aurelie Hirschler, Christine Carapito, Nicodème Paul, Raphael Carapito, Matthias Mörgelin, Uwe Hansen, Joyce Azzi, Lucie Aubergeon, Nathalie Salomé, Sayda Dhaouadi, Pierre Grenot, Balkiss Bouhaouala-Zahar, Simona La Cioppa, Philippe Oertle, Valerio Izzi, Marija Plodinec, Georges Noel, Hélène Burckel, Gertraud Orend   +30 more
doaj   +1 more source

Coral Chronicles Quarterly Newsletter

The Coral Chronicles Quarterly Newsletter, published by The Nature Conservancy (TNC), disseminates scientific insights, conservation strategies, and regional collaborations on coral reef ecosystems in the Caribbean and beyond.
The Nature Conservancy (TNC)
core  

The collective application of shorebird tracking data to conservation

Conservation Biology, EarlyView.
Abstract Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership
Autumn‐Lynn Harrison, Candace Stenzel, Alexandra Anderson, Jessica Howell, Richard B. Lanctot, Marley Aikens, Joaquín Aldabe, Liam A. Berigan, Joël Bêty, Erik Blomberg, Juliana Bosi de Almeida, Andy J. Boyce, David W. Bradley, Stephen Brown, Jay Carlisle, Edward Cheskey, Katherine Christie, Sylvain Christin, Rob Clay, Ashley Dayer, Jill L. Deppe, Willow English, Scott A. Flemming, Olivier Gilg, Christine Gilroy, Susan Heath, Jason M. Hill, J. Mark Hipfner, James A. Johnson, Luanne Johnson, Bart Kempenaers, Paul Knaga, Eunbi Kwon, Benjamin J. Lagassé, Jean‐François Lamarre, Christopher Latty, Don‐Jean Léandri‐Breton, Nicolas Lecomte, Pam Loring, Laura A. McDuffie, Rebecca McGuire, Scott Moorhead, Juan G. Navedo, David Newstead, Erica Nol, Alina Olalla‐Kerstupp, Bridget Olson, Elizabeth Olson, Julie Paquet, Allison K. Pierce, Jennie Rausch, Kevin Regan, Matthew E. Reiter, Amber M. Roth, Mike Russell, Daniel Ruthrauff, Sarah T. Saalfeld, Amy L. Scarpignato, Shiloh Schulte, Nathan R. Senner, Joseph A. M. Smith, Paul A. Smith, Zach Spector, Kelly Srigley Werner, Michelle L. Stantial, Audrey R. Taylor, T. Lee Tibbitts, Mihai Valcu, Nils Warnock, Walter Wehtje, Brad Winn, Michael B. Wunder   +71 more
wiley   +1 more source

Producing a Red List of Ecosystems for the Brazilian Cerrado

Conservation Science and Practice, EarlyView.
Land clearance is a key driver of biodiversity loss. This is a particular issue in the Brazilian Cerrado, the world's most biodiverse savanna biome and a region experiencing the rapid expansion of agriculture. By using the Red List of Ecosystems as an international standard, we provide the first globally comparable analysis of the state of the Cerrado,
Juliana Ávila Martins, Robert J. Smith
wiley   +1 more source

INTERNATIONALIZATION OF INNOVATION ACTIVITY BY TNCS

JOURNAL OF EUROPEAN ECONOMY, 2017
The article analyses main stages in the internationalization of innovation activity undertaken by transnational companies and offers a generalization of approaches to its various forms. The analysis of the process of R&D internationalization was carried out based on the roles of subsidiaries in the general structure (network) of TNCs. The study of
openaire   +1 more source

Integrating social science into conservation practice: Evidence from environmental non‐governmental organization publications and practitioner perspectives

Conservation Science and Practice, EarlyView.
We analyzed 700 peer‐reviewed articles with co‐authors from the 4 largest international environmental non‐governmental organizations (ENGOs) 1998–2023 and interviewed 8 scientists and conservation managers of projects at The Nature Conservancy (TNC) on 4 continents. Conservation social science papers have increased from 1.7% in 1998, holding steady at ~
Jensen Reitz Montambault, Helena Cardenas‐Diaz, Matthew Selinske, Zhixian Luo, James Thomas Erbaugh, Philip A. Loring, Priya Shyamsundar   +6 more
wiley   +1 more source