Results 271 to 280 of about 1,383,229 (318)

Model-Based Design of Sustained-Release Formulations of Anti-TNF-α Monoclonal Antibodies for Intravitreal Administration. [PDF]

Pharmaceutics
Reig-López J, Cuquerella-Gilabert M, Zarzoso-Foj J, Mangas-Sanjuán V, Merino V, Merino-Sanjuán M.   +5 more
europepmc   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Prolonged TNF-α stimulation induces a PD-1-associated exhaustion-like phenotype in mesenchymal stromal cells. [PDF]

Front Cell Dev Biol
Matsunaga N, Akiyama K, Mun AY, Zou T, Ito K, Tagashira R, Kuboki T.   +6 more
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Mycobacterium decipiens Infection in Patient Receiving Anti-TNF-α Therapy, France, 2024. [PDF]

Emerg Infect Dis
Destoop JC, Poignon C, Danjou W, Bleibtreu A, Pourcher V, Monsel G.   +5 more
europepmc   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Splenic Tuberculosis in a Patient With Crohn's Disease Receiving Anti-tumor Necrosis Factor-α (TNF-α) Therapy: A Case Report. [PDF]

Cureus
Boucaid A, Tiresse N, Zegmout A, Souhi H, Rhorfi I, Elouazzani H.   +5 more
europepmc   +1 more source

Association of Oral Contraceptives Consumption with C-Reactive Protein (CRP), Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL-6) in Female in vivo Model

International Journal of Biological Chemistry
Barizoge Cletus Lemii, Iyaeneomi Ransome Daka, Christine Umanu Gabriel-Brisibe, Sarah Kelechi Enebeli, Ucheawaji Felicia Edward, Iyingiala Austin-Asomeji, Efekemo Oghenetekevwe, Nodi Conquest Chivusalem, Tamuno-Boma Odinga-Israel   +8 more
openaire   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Hepatobiliary disorders associated with TNF-α inhibitors: a pharmacovigilance analysis of FAERS and JADER. [PDF]

Front Immunol
Chen H, Jiang S, Wang J, Zhang A, Zhu L.
europepmc   +1 more source