Results 301 to 310 of about 3,516,666 (358)

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

TNF-α deficiency underlies NK cell dysfunction in colorectal cancer. [PDF]

Oncoimmunology
Ruggeri S, Pizzitola B, Laffranchi M, Beltrame L, Sciumé G, Grimaldi A, Fiori E, Caronna R, De Peppo V, Grazi GL, Laquintana V, Turri G, Sozzani S, Gismondi A, Fionda C, Santoni A, Stabile H.   +16 more
europepmc   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

Elevated serum TNF-α in patients with immune-mediated necrotizing myopathy correlates with muscle damage. [PDF]

BMC Immunol
Han X, Ge H, Zhang Q, Yang M, Bu B.
europepmc   +1 more source

Association of Oral Contraceptives Consumption with C-Reactive Protein (CRP), Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL-6) in Female in vivo Model

International Journal of Biological Chemistry
Barizoge Cletus Lemii, Iyaeneomi Ransome Daka, Christine Umanu Gabriel-Brisibe, Sarah Kelechi Enebeli, Ucheawaji Felicia Edward, Iyingiala Austin-Asomeji, Efekemo Oghenetekevwe, Nodi Conquest Chivusalem, Tamuno-Boma Odinga-Israel   +8 more
openaire   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Multiscale modeling uncovers macrophage infiltration and TNF-α signaling networks for targeting in inflammatory breast cancer tumor emboli. [PDF]

Breast
Pai P, Van Berckelaer C, Van Laere S, Bennion A, Charity T, Yang J, Bertucci F, Van Dam P, Palmer GM, McCall S, Dirix LY, Ueno NT, Devi GR.   +12 more
europepmc   +1 more source

A novel role of the TNF-α/p65/IRF1 axis in aggravating rheumatoid arthritis through the induction of fibroblast-like synoviocytes pyroptosis. [PDF]

Front Pharmacol
Jia Q, Zhang X, Jiang L, Zhang Z, Li Z, Wang Y, Yan P.   +6 more
europepmc   +1 more source

Tissue-adhesive hydrogel-MXene biosensor for in situ intraoral TNF-α detection. [PDF]

Sci Adv
Wong TH, Liu W, Li J, Ma J, Cheng Y, Lu R, Koster KJ, Cirillo JD, Liu X, Sasaki H, Wu C, Lin S.   +11 more
europepmc   +1 more source