Results 11 to 20 of about 1,312,052 (154)

TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease [PDF]

Nature Communications
TNF inhibitors have been used to treat autoimmune and autoinflammatory diseases. Here we report an unexpected mechanism underlying the therapeutic effects of TNF inhibitors in Behçet’s disease (BD), an autoimmune inflammatory disorder.
Menghao Zhang, Na Kang, Xin Yu, Xiaoyang Zhang, Qinghui Duan, Xianqiang Ma, Qiancheng Zhao, Zhimian Wang, Xiao’ou Wang, Yeling Liu, Yuxiao Zhang, Can Zhu, Ruiyu Gao, Xin Min, Cuifeng Li, Jin Jin, Qian Cao, Rongbei Liu, Xiaoyin Bai, Hong Yang, Lidan Zhao, Jinjing Liu, Hua Chen, Yonghui Zhang, Wanli Liu, Wenjie Zheng   +25 more
doaj   +3 more sources

Pharmacogenomics of TNF inhibitors [PDF]

Frontiers in Immunology
Tumor necrosis factor alpha inhibitors (TNFi) are biologic drugs that target TNFα, a key pro-inflammatory cytokine, to suppress disease activity and alleviate symptoms of various autoimmune diseases, including inflammatory bowel disease.
Zainab Jan, Farah El Assadi, Dinesh Velayutham, Borbala Mifsud, Borbala Mifsud, Puthen Veettil Jithesh, Puthen Veettil Jithesh   +6 more
doaj   +2 more sources

IL-6 Inhibitors and TNF Inhibitors [PDF]

JACC: Basic to Translational Science
Summary: Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects.
Simon Jønck, MD, PhD, Malte Lund Adamsen, MD, Iben E. Rasmussen, MSc, Anna A. Lytzen, MSc, Mathilde Løk, BSc, Morten Asp Vonsild Lund, MD, Lene Dreyer, MD, PhD, Peter G. Jørgensen, MD PhD, Niels Vejlstrup, MD, Lars Køber, MD, DMSc, Robin Christensen, MSc, PhD, Søren Jacobsen, MD, DMSc, Bente Klarlund Pedersen, MD, DMSc, Helga Ellingsgaard, MSc, PhD, Pil Højgaard, MD, PhD, Ronan M.G. Berg, MD, DMSc, Regitse Højgaard Christensen, MD, PhD   +16 more
doaj   +2 more sources

Cost-effectiveness of abatacept, tocilizumab and TNF-inhibitors compared with rituximab as second-line biologic drug in rheumatoid arthritis. [PDF]

PLoS ONE, 2019
ObjectivesThe objective of this study was to evaluate the cost-effectiveness of abatacept, tocilizumab, and tumor necrosis factor (TNF) inhibitors as compared with rituximab in Finnish rheumatoid arthritis patients, who have previously been treated with ...
Saara Huoponen, Kalle J Aaltonen, Jaana Viikinkoski, Jarno Rutanen, Heikki Relas, Kirsi Taimen, Kari Puolakka, Dan Nordström, Marja Blom   +8 more
doaj   +4 more sources

Differential regulation of TNF-α and IL-1β production from endotoxin stimulated human monocytes by phosphodiesterase inhibitors [PDF]

Mediators of Inflammation, 1992
The effect of selective PDE-I (vinpocetine), PDE-III (milrinone, CI-930), PDE-IV (rolipram, nitroquazone), and PDE-V (zaprinast) isozyme inhibitors on TNF-α and IL-1β production from LPS stimulated human monocytes was investigated.
K. L. Molnar-Kimber, L. Yonno, R. J. Heaslip, B. M. Weichman   +3 more
doaj   +2 more sources

Longer Drug Retention of Interleukin-12/23 or Interleukin-17 Inhibitors Compared With TNF Inhibitors in Female Patients With TNF Inhibitor-Experienced Psoriatic Arthritis [PDF]

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Objective: To compare the effectiveness of Interleukin (IL)-12/23 or IL-17A inhibitors (summarized to inhibitors of the Th17 cell generation or function, Th17i) with tumor necrosis factor inhibitors (TNFi) in patients with TNFi-experienced psoriatic ...
Godehard A. Scholz, MD, PhD, Eleftherios Papagiannoulis, MSc, Christoph Blapp, MSc, Raphael Micheroli, MD, Adrian Ciurea, MD, Michael J. Nissen, MD, Nikhil Yawalkar, MD, Diana Dan, MD, Jennifer Amsler, MD, Almut Scherer, PhD, Burkhard Möller, MD   +10 more
doaj   +2 more sources

The Role of Non-Selective TNF Inhibitors in Demyelinating Events [PDF]

Brain Sciences, 2021
The use of non-selective tumor necrosis factor (TNF) inhibitors is well known in the treatment of inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, and psoriasis.
Line Buch Kristensen, Kate Lykke Lambertsen, Nina Nguyen, Keld-Erik Byg, Helle H Nielsen   +4 more
doaj   +2 more sources

Therapeutic TNF Inhibitors Exhibit Differential Levels of Efficacy in Accelerating Cutaneous Wound Healing [PDF]

JID Innov
Therapeutic TNF Inhibitors Exhibit Differential Levels of Efficacy in Accelerating Cutaneous Wound ...
BP Harvey (16215653), HM Robb (20891144), K White (9583325), Y Cao (7653362), J Wang (20900), Y Yang (6099497), MP Macoritto (20891150), C Hu (8184405), Munish Puri (13085961), L Jin (7409639), Y Liu (4702669), X Wang (1378959), KM Smith (15827273), X Xin (13565047), S Tanriverdi (20891147), S Westmoreland (20891141), TRDJ Radstake (20891153), Z Kaymakcalan (20891156), Y Tian (8473476)   +18 more
core   +2 more sources

Influence of TNF-α Inhibitors on Gut Microbiota and Immune Modulation in Treating Ankylosing Spondylitis: Insights into Therapeutic Mechanisms and Clinical Implications [PDF]

Journal of Inflammation Research
Yue-Xing Yuan,1,* Shou-Rui Feng,2,* Ai-Yu Wu,1 Wei-Hao Wu,1 Pan Tian,1 Ai-Zhen Chen,1 Xiao-Mei Ma,1 Ling-Ling Huang,1 Lian Yu1 1Department of Hematology and Rheumatology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan ...
Yuan YX, Feng SR, Wu AY, Wu WH, Tian P, Chen AZ, Ma XM, Huang LL, Yu L   +8 more
doaj   +1 more source

Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition

Medical Mycology Case Reports, 2019
Endemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection.
Theodore Wright, Basak Coruh, David Fredricks, Nina Kim   +3 more
doaj   +2 more sources