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Targeting PAR1 biased signaling with parmodulin reduces thromboinflammation and acute lung injury in sickle cell disease. [PDF]

Blood Adv
Ramadas N, Lowder K, Dutton J, Kazen RC, Sellers R, DeRousse JT, Dockendorff C, Sparkenbaugh EM.   +7 more
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TNF receptor 2 pathway: drug target for autoimmune diseases

Nature Reviews Drug Discovery, 2010
Although drug development has advanced for autoimmune diseases, many current therapies are hampered by adverse effects and the frequent destruction or inactivation of healthy cells in addition to pathological cells. Targeted autoimmune therapies capable of eradicating the rare autoreactive immune cells that are responsible for the attack on the body's ...
Denise, Faustman, Miriam, Davis
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Anti-inflammatory TNF receptor 2 signalling unravelled

Nature Reviews Rheumatology, 2021
A new study describes an anti-inflammatory signalling pathway mediated by TNFR2 and the signalling molecule 14-3-3e and the effects of this pathway on macrophage polarization.
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Collagen-Induced Arthritis in TNF Receptor-1-Deficient Mice: TNF Receptor-2 Can Modulate Arthritis in the Absence of TNF Receptor-1

Clinical Immunology, 2001
TNF is a potent proinflammatory cytokine important for the development of arthritis in human and animals. We have investigated the roles of TNF receptor-1 (TNFR1) and TNF receptor-2 (TNFR2) in collagen-induced arthritis (CIA) by inducing CIA in mice genetically deficient in TNFR1. TNFR1-/- mice developed arthritis with similar incidence and severity as
Y, Tada, A, Ho, S, Koarada, F, Morito, O, Ushiyama, N, Suzuki, Y, Kikuchi, A, Ohta, T W, Mak, K, Nagasawa   +9 more
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Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

International Archives of Allergy and Immunology, 2021
<b><i>Introduction:</i></b> Modulating specific biological effects through the changes in cytokine receptors’ expression level remains poorly understood. This study aimed to investigate the influence of the dose-dependent effect of TNF on the balance between proapoptotic and proliferation response depending on the parameters of ...
Alina Alshevskaya, Olga Koneva, Irina Belomestnova, Julia Lopatnikova, Irina Evsegneeva, Julia Zhukova, Fedor Kireev, Aleksander Karaulov, Sergey Sennikov   +8 more
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Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site.

The Journal of Immunology, 1997
Abstract TNFR p60 (TNFR60) is the main mediator of TNF-induced apoptosis, although in some cells TNFR80 is also involved. TNFR80-dependent induction or enhancement of cytotoxicity has been explained by intracellular signaling, "ligand passing," or induction of endogenous TNF.
T, Weiss, M, Grell, B, Hessabi, S, Bourteele, G, Müller, P, Scheurich, H, Wajant   +6 more
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TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress

Biochemical and Biophysical Research Communications, 2013
The neuroprotective role of TNF receptor 2 (TNFR2) has been shown in various studies. However, a direct role of TNFR2 in oligodendrocyte function has not yet been demonstrated. Using primary oligodendrocytes of transgenic mice expressing human TNFR2, we show here that TNFR2 is primarily expressed on oligodendrocyte progenitor cells.
Olaf, Maier, Roman, Fischer, Cristina, Agresti, Klaus, Pfizenmaier   +3 more
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Characterization of TNF receptor type 2 isoform in the mouse

Molecular Immunology, 2007
In this report a TNF receptor type 2 (TNFR2) isoform in the mouse, termed micp75TNFR, was compared to its human orthologue hicp75TNFR and to the known mouse TNFR2. The micp75TNFR is generated by the use of an alternative transcriptional start site within the mouse TNFR2 gene.
Andrea, Hauser, Thomas, Hehlgans, Daniela N, Männel   +2 more
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Crucial Role of TNF Receptor Type 1 (p55), But Not of TNF Receptor Type 2 (p75), in Murine Toxoplasmosis

The Journal of Immunology, 1998
AbstractTNF-α exerts its biologic activity through two distinct receptors, TNF receptor type 1 (TNFR1, p55) and TNF receptor type 2 (TNFR2, p75). To analyze their function in toxoplasmosis, we orally infected mice genetically deficient for TNFR1 (TNFR10/0), TNFR2 (TNFR20/0), or both TNF receptors (TNFR1/20/0), as well as wild-type (wt) mice with a low ...
M, Deckert-Schlüter, H, Bluethmann, A, Rang, H, Hof, D, Schlüter   +4 more
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