Results 141 to 150 of about 8,658 (259)

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward   +4 more
wiley   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

On Poisson's ratio for metal matrix composite laminates [PDF]

open access: yes
The definition of Poisson's ratio for nonlinear behavior of metal matrix composite laminates is discussed and experimental results for tensile and compressive loading of five different boron-aluminum laminates are presented. It is shown that there may be
Herakovich, C. T., Shuart, M. J.
core   +1 more source

Wrestling Voices: Amplifying Patriotism and Ethnic Stereotypes in 1980s American Professional Wrestling

open access: yesThe Journal of American Culture, EarlyView.
ABSTRACT This article examines the use of promotional interviews (“promos”) in American professional wrestling of the 1980s. I argue that promos introduced a vocal modality into a form of sports entertainment that, as Roland Barthes ([1957] 1972) showed in Mythologies, had always been dominated by visual spectacle. I then undertake a focused linguistic
Jens Kjeldgaard‐Christiansen
wiley   +1 more source

Circular RNA Vv‐circCOR27 modulates thermotolerance through attenuating VvHSP90.2b‐VvHsfA7a interaction in grapevine

open access: yesNew Phytologist, EarlyView.
Summary Circular RNAs (circRNAs) are single‐stranded, covalently closed RNA molecules that arise from exon back‐splicing. The identification and function investigation of circRNAs have been comprehensively explored in plants, however, the regulatory mechanisms are largely unknown.
Yi Ren   +14 more
wiley   +1 more source

Myocardial and Neural Damage due to Pulmonary Vein Isolation: Comparison of Pulsed Electric Field and Thermal Ablation

open access: yesPacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Pulmonary vein isolation (PVI) using thermal energy—radiofrequency (RF) or cryoablation (CRYO)—is associated with direct myocardial injury and collateral neural damage. In contrast, pulsed electric field (PEF) energy has emerged as a neural‐sparing alternative.
Predrag Stojadinović   +12 more
wiley   +1 more source

The Diversity of the DNA‐Binding Landscape in the DREB/ERF Family: Focusing on Reproductive Processes in Fruit Trees With Highly Heterozygous Genome

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT DREB/ERF transcription factors play pivotal roles in plant development; however, their structural characteristics, DNA‐binding preferences, and functional roles in highly heterozygous woody plants remain insufficiently understood. Using lychee (Litchi chinensis) as a model, we identified 95 DREB/ERF genes subdivided into ten phylogenetic ...
Fengqi Wu   +9 more
wiley   +1 more source

GmMYB4 Positively Regulates Isoflavone Biosynthesis via the GmMAPK6‐GmMYB4‐MBW Module in Soybean

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Isoflavones, a class of bioactive compounds predominantly found in leguminous plants, are largely responsible for their beneficial effects on human health. Although MYB transcription factors (TFs) are known to be crucial regulators of isoflavone biosynthesis in soybean, the precise mechanisms underlying their regulatory functions remain poorly
Changyun Yang   +12 more
wiley   +1 more source

An Instrument for Recording the Position of Airplane Control Surfaces [PDF]

open access: yes
N.A.C.A. has developed an instrument which makes a continuous record of the angular position of the control surfaces of an airplane, not only in steady flight but during acrobatics as well.
Ronan, K M
core   +1 more source

WRKY27‐RAP2.7 Regulatory Module Promotes Cold Tolerance via Modulation of Lignin Biosynthesis and Redox Homeostasis by Regulating Cinnamyl Alcohol Dehydrogenase 7 and Glutathione S‐Transferase F6

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Cold stress adversely affects plant growth and development, significantly limiting fruit yield and quality in citrus. Ichang papeda (Citrus ichangensis), a cold‐tolerant citrus species, serves as a valuable genetic resource for studying cold adaptation, yet the key genes and their modes of action underlying the cold stress response remain ...
Jing Qu   +6 more
wiley   +1 more source

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