Results 251 to 260 of about 614,943 (309)

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Changes in tobacco sales before, during, and after the COVID-19 pandemic in Japan: An interrupted time series analysis. [PDF]

PLoS One
Kondo K, Morita I, Sakuma S, Ohsawa I.
europepmc   +1 more source

Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Sidharth Anand, Nicholas A. Buckley, Paul Stathakis, Laura James, Larry Parker, Mitchell R. McGill, Angela L Chiew   +6 more
wiley   +1 more source

Cannabis and Tobacco Product Use Classes and Psychosocial Correlates Among US Young Adults. [PDF]

Nicotine Tob Res
Speer M, Cui Y, McCready DM, LoParco CR, Romm KF, Wang Y, Schubel LC, Howlader A, Williams J, Thakkar S, Cavazos-Rehg PA, Berg CJ.   +11 more
europepmc   +1 more source

Tobacco smoke exposure and spine fracture risk in US adults: A cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2010, 2013-2014, 2017-2020. [PDF]

Tob Induc Dis
Zhang R, Long W, Li Y.
europepmc   +1 more source

Progress in understanding the infection mechanisms, soil microecological imbalance, and integrated control strategies of tobacco black shank. [PDF]

Front Microbiol
Wei X, Tian N, Mei W, Li J, Liu M, Zhou H, Yang Z, Yang C, Hu Y.   +8 more
europepmc   +1 more source

Systematic Assessment of Flavor Cues and Additives in Cigarettes and Heated Tobacco Products in Korea: Cross-Sectional Surveillance Study. [PDF]

JMIR Public Health Surveill
Heo G, Kim D, Kim Y, Kim A, Cho N, Kang N, Park J, Cheon E, Kim S, Park S, Park S, Cho SI, Kang H.   +12 more
europepmc   +1 more source