Results 61 to 70 of about 16,491,459 (401)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Global Regulatory Strategies for Tobacco Control [PDF]

open access: yes, 2007
Recent tobacco control regulation in North America and Western Europe has had a salutary effect, even if smoking remains a pressing public health hazard.
Gostin, Lawrence O.
core   +3 more sources

Tobacco Tax Index 2017: assessing implementation of WHO FCTC Article 6 in ASEAN countries

open access: yesTobacco Induced Diseases, 2018
Background and challenges to implementation Because tobacco is a threat to sustainable social development, tobacco tax policy will play a significant role in achieving the 2030 Sustainable Development Goals (SDGs) to end poverty, protect the planet, and ...
Sophapan Ratanachena, Ulysses Dorotheo
doaj   +1 more source

Similarities and Differences in Tobacco Control Research Findings From Convenience and Probability Samples.

open access: yesAnnals of Behavioral Medicine, 2018
BACKGROUND Online convenience samples are a quick and low-cost way to study health behavior, but the comparability to findings from probability samples is not yet well understood.
M. Jeong   +7 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

The United States\u27 Engagement in Global Tobacco Control: Proposals for Comprehensive Funding and Strategies [PDF]

open access: yes, 2010
Tobacco use kills more people annually than HIV/AIDS, tuberculosis, and malaria combined. Unless action is taken, tobacco-related diseases will kill hundreds of millions more in coming decades, mostly in low- and middle-income countries.
Bollyky, Thomas J., Gostin, Lawrence O.
core   +1 more source

Perspectives on Tobacco Product Waste: A Survey of Framework Convention Alliance Members' Knowledge, Attitudes, and Beliefs. [PDF]

open access: yes, 2015
Cigarette butts (tobacco product waste (TPW)) are the single most collected item in environmental trash cleanups worldwide. This brief descriptive study used an online survey tool (Survey Monkey) to assess knowledge, attitudes, and beliefs among ...
Curtis, Clifton   +5 more
core   +4 more sources

Ten years of India´s National Tobacco Control Programme: achievements, challenges and the way forward

open access: yesTobacco Induced Diseases, 2018
Background and challenges to implementation In India, more than 275 million adults use tobacco, which kills 1.2 million of these every year. More than one-quarter of India´s youth begin tobacco use before they are 16 years old and 85% of all users begin
Ashish Kumar Pandey   +5 more
doaj   +1 more source

Exceeding FCTC obligations: Nepal overcoming tobacco industry interference to enact a comprehensive tobacco control policy.

open access: yesNicotine & Tobacco Research, 2019
BACKGROUND The tobacco industry works to block, delay and weaken national tobacco control legislation to implement the FCTC. This paper reviews how Nepal overcame industry opposition and to a comprehensive tobacco control law implementing the FCTC ...
D. Bhatta   +3 more
semanticscholar   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

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