Results 161 to 170 of about 2,189,319 (256)

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke, Diego M. Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane A. Sievi, Marco Di Donato, Anton Schmick, Jonas Herth, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +12 more
wiley   +1 more source

Prenatal Alcohol and/or Tobacco Exposure, White-Matter Microstructure, and Cognition: Analyzing a South African Birth Cohort With Neurite Orientation and Dendrite Dispersion Imaging. [PDF]

Alcohol Clin Exp Res (Hoboken)
Kan E, Marshall AT, Jonker D, Butler-Kruger L, Charles W, Petersen A, Brink LT, Ipser JC, Joshi SH, Narr KL, Odendaal HJ, Scheffler F, Donald KA, Stein DJ, Sowell ER.   +14 more
europepmc   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

The platelet-to-high-density lipoprotein cholesterol ratio as a potential biomarker linking tobacco exposure to accelerated reproductive aging in women: A cross-sectional study. [PDF]

Medicine (Baltimore)
Liao J, Qiong, Zhuoma D, Ning W, Ga D, Quncuo S, Jing J, Li L, Li Y, Li X, Lv B, Chen H.   +11 more
europepmc   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Serum cotinine-assessed tobacco exposure, cadmium co-exposure, and childhood obesity: a cross-sectional study. [PDF]

Environ Health
Guo F, Ding C, Gu S, Shi W, Zhang X, Qu Y, Xu P, Mo Z, Wang X, Yan S, Sun P, Zhao F, Zhu Y, Lv Y, Chen Z, Shi X, Lou X.   +16 more
europepmc   +1 more source

The Kansas Youth Tobacco Survey Data Highlights 2009-2010.

, 2010
application/pdf; Caption title.; "This document contains major highlights of the 2009/2010 Kansas Youth Tobacco Survey ...
Kansas. Tobacco Use Prevention Program.
core  

Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset

Clinical Pharmacology &Therapeutics, EarlyView.
Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit, Maaike van Dartel, Laura Rodwell, Hanneke van der Woude, Cornelis Boersma, Peter G. M. Mol, Doranne Hilarius   +6 more
wiley   +1 more source

Sexually dimorphic response to tobacco exposure in COPD: a systematic review and meta-analysis. [PDF]

BMC Pulm Med
Chow R, Pham M, Cope M, Wang J, Ghasemi R, Yang S, Le Nguyen D, Abdul SA, Sadh S, Xiang A, Ambade P, Frances R, Shorr R, Pakhale S.   +13 more
europepmc   +1 more source

Speaking About Artificial Intelligence for Sustainability—How Employees’ Perception of Credibility Shapes Their Initial Attitudes Toward AI Adoption

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Companies increasingly claim to adopt artificial intelligence (AI) not only for economic but also for ecological and social purposes. However, in light of rising greenwashing, bluewashing, and ethics washing, the impact of the communicated rationale on employees' initial attitude toward AI introduction remains unclear.
Marco Baumgartner, Tobias Kopp, Regina Kempen, Steffen Kinkel   +3 more
wiley   +1 more source