Results 221 to 230 of about 3,615,602 (379)

Harnessing Viral Proteases for Cellular and Molecular Engineering

open access: yesChemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui   +2 more
wiley   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano   +8 more
wiley   +1 more source

Tobacco industry pricing strategies for single cigarettes and multistick packs after excise tax increases in Colombia. [PDF]

open access: yesTob Control, 2023
Sheikh ZD   +5 more
europepmc   +1 more source

Farming Exit Decision by Age Group: Analysis of Tobacco Buyout Impact in Kentucky [PDF]

open access: yes
This article analyzes factors that affected the decision to exit tobacco production in the wake of the tobacco buyout program using the data collected through a survey of Kentucky tobacco farmers.
Pushkarskaya, Helen N.   +1 more
core   +1 more source

Absolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double‐Blind, Placebo‐Controlled, Crossover Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Lysergic acid diethylamide (LSD) is currently being investigated as a potential treatment for psychiatric and neurological disorders. Different LSD formulations (base or tartrate, oral or intravenous) are being used. Unclear is whether LSD base and tartrate pharmacokinetics are equivalent.
Denis Arikci   +7 more
wiley   +1 more source

Uncovering ESG Ratings: The (Im)Balance of Aspirational and Performance Features

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Environmental, Social, and Governance (ESG) scores are crucial for evaluating corporate sustainability. However, the undisclosed and complex methodologies used by rating agencies have raised concerns about their reliability and consistency. This study replicates LSEG's ESG scoring methodology using machine learning to shed light on the key ...
Andrea Ferro   +2 more
wiley   +1 more source

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