Results 161 to 170 of about 4,209 (214)

Tocolytic effects of intravenous nitroglycerin

Fundamental & Clinical Pharmacology, 2004
AbstractCurrently available tocolytic agents have shown partial or transient efficacy on uterine contractions delaying delivery for 24 or 48 h without reduction in perinatal morbidity and mortality. These facts led us to study a new tocolytic compound.
Marina, de Spirlet, Jean-Marc, Treluyer, Sylvie, Chevret, Elisabeth, Rey, Michel, Tournaire, Dominique, Cabrol, Gérard, Pons   +6 more
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Leptin – A tocolytic agent for the future?

Medical Hypotheses, 2010
Leptin - a protein hormone is synthesised in the adipose tissue in humans. Its level therefore should be directly proportional to the amount of adipose tissue in the body. When biopsies of human myometrium from obese women were exposed to leptin, it showed a cumulative inhibitory effect on spontaneous as well as induced contractions.
Rekha, Wuntakal, Tony, Hollingworth
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Prostaglandin inhibitors as tocolytic agents

Seminars in Perinatology, 2001
Indomethacin, a nonspecific prostaglandin synthetase inhibitor, gained popularity several decades ago as a potent tocolytic agent. This popularity, however, was tempered by concerns over fetal and neonatal complications associated with its use. However, with better recognition of the safety limitations, there has been a renewed interest in using ...
S T, Vermillion, C N, Landen
openaire   +2 more sources

TOCOLYTICS FOR PRETERM LABOR

Obstetrics & Gynecology, 1999
To examine the effectiveness of any tocolytic compared with a placebo or no tocolytic for preterm labor.We checked MEDLINE (1966-1998) and the Cochrane Controlled Trials Register for articles, using the search terms "randomized controlled trial" (RCT), "preterm labor," "tocolysis," "betamimetics," "ritodrine," "terbutaline," "hexaprenaline ...
K, Gyetvai, M E, Hannah, E D, Hodnett, A, Ohlsson   +3 more
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Calcium channel blockers as tocolytics

Seminars in Perinatology, 2001
This article reviews the clinical and basic science investigations regarding the safety and efficacy of calcium channel blockers as tocolytic agents. The authors reviewed the English language literature on the pharmacology and clinical applications of calcium antagonists in obstetrics.
K E, Economy, A Z, Abuhamad
openaire   +2 more sources

Tocolytic Therapy: A Meta-analysis and Decision Analysis

Obstetric Anesthesia Digest, 2009
To determine the optimal first-line tocolytic agent for treatment of premature labor.We performed a quantitative analysis of randomized controlled trials of tocolysis, extracting data on maternal and neonatal outcomes, and pooling rates for each outcome across trials by treatment. Outcomes were delay of delivery for 48 hours, 7 days, and until 37 weeks;
David M, Haas, Thomas F, Imperiale, Page R, Kirkpatrick, Robert W, Klein, Terrell W, Zollinger, Alan M, Golichowski   +5 more
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Frequently asked questions on tocolytics

BJOG: An International Journal of Obstetrics & Gynaecology, 2005
The majority of drugs that are used today for tocolysis have been developed for clinical conditions other than preterm labour. Obstetricians started to use these drugs as tocolytics because of their additional influence on uterine smooth muscle relaxation, accepting their cardiovascular (side) effects.
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The contemporary use of tocolytics

Current Obstetrics & Gynaecology, 2000
Abstract Preterm birth is the leading cause of perinatal mortality and morbidity in the developed world. Worldwide, it is estimated that 13 million babies are born preterm each year and in Europe there are approximately 100 000 potentially preventable preterm births per annum.
P.J. Greenfield, R.F. Lamont
openaire   +1 more source

Perinatal Death and Tocolytic Magnesium Sulfate

Obstetrics & Gynecology, 2000
To determine whether there is a significant association between perinatal mortality and exposure to total doses of tocolytic magnesium sulfate larger than 48 g.We did a case-control study in which cases were defined as neonates or fetuses who died after being exposed to tocolytic magnesium sulfate and controls were those who survived exposure.
R, Scudiero, B, Khoshnood, P G, Pryde, K S, Lee, S, Wall, R, Mittendorf   +5 more
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What’s New in Tocolytics

Clinics in Perinatology, 1992
Tocolytic therapy represents the final obstetric end point in the prevention of premature births. For the past two decades, betamimetic therapy has been the mainstay of tocolytic therapy. Newer agents, indomethacin and nifedipine, offer new hope in the treatment of premature labor.
Michael R. Leonardi, Gary D.V. Hankins
openaire   +1 more source