Results 1 to 10 of about 1,520 (125)

Combination of tocolytic agents for inhibiting preterm labour [PDF]

The Cochrane Library, 2014
Preterm birth represents the single largest cause of mortality and morbidity for newborns and a major cause of morbidity for pregnant women. Tocolytic agents include a wide range of drugs that can inhibit labour to prolong pregnancy. This may gain time to allow the fetus to mature further before being born, permit antenatal corticosteroid ...
Joshua P Vogel, Thérèse Dowswell, Olufemi T Oladapo   +2 more
exaly   +4 more sources

Synergistic effects of nifedipine and indomethacin in tocolysis: A translational study. [PDF]

Int J Gynaecol Obstet
International Journal of Gynecology &Obstetrics, Volume 171, Issue 3, Page 1418-1420, December 2025.
Yart L, Cohen M, Martinez de Tejada B.
europepmc   +2 more sources

Effects of sympathomimetic tocolytic agents on the fetus [PDF]

Journal of Perinatal Medicine, 1974
The variety of factors controlling the onset of parturition, as well as the very complex mechanisms which physiologically maintain pregnancy by inhibiting uterine contractions are only partially understood today. As long as the triggering mechanisms, and the conditions favoring timely and early labor are incompletely known, symptomatic therapeutic ...
exaly   +3 more sources

School Performance After Maintenance Tocolysis With Nifedipine for Threatened Preterm Birth: 12-Year Follow-Up of the APOSTEL 2 Trial. [PDF]

BJOG
ABSTRACT Objective To evaluate school performance at 12 years of age in children prenatally exposed to maintenance tocolysis with nifedipine versus placebo. Design 12‐year follow‐up of the multicentre APOSTEL 2 trial, in which participants with threatened preterm birth between 26+0 and 32+2 weeks of gestation, who remained pregnant after initial 48‐h ...
van der Windt LI, Meliezer JAL, Pajkrt E, Spaanderman MEA, Scheepers HCJ, Mol BW, Oudijk MA, Ravelli ACJ, Roos C.   +8 more
europepmc   +2 more sources

The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents. [PDF]

Int J Endocrinol, 2011
Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which belongs to the G-protein-coupled receptor superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the ...
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z.   +4 more
europepmc   +6 more sources

Cost-effectiveness of antenatal corticosteroids and tocolytic agents in the management of preterm birth: A systematic review [PDF]

EClinicalMedicine, 2022
Elizabeth Sebastian, Alexander John Eggleston, Katherine E Eddy   +2 more
exaly   +2 more sources

Tocolytic agents and the failure to improve neonatal outcomes

Pregnancy
Abstract Premature delivery has long been a major problem in obstetrics. Increased perinatal morbidity and mortality as well as substantial health care costs, both short and long term, have driven the efforts to combat this complication. While multiple agents have been studied over the last 70 years leading to hundreds of publications
Jack FitzSimmons, Emily Oliver
openaire   +2 more sources

Efficacy of oral nifedipine as a tocolytic agent

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2021
Background: Preterm birth is defined as birth at less than 37 weeks period of gestation, is the most important single determinant of adverse infant outcome in terms of both survival and quality of life. The need for tocolysis in terms of safety and efficacy is necessary to decrease perinatal mortality and morbidity in preterm labour.
Veena Bikkolli Teekappa Gowda, Madhubala Kalidoss   +1 more
openaire   +2 more sources

Priming of labor with tafoxiparin in nulliparous term pregnant women with unripe cervix—Proof‐of‐concept and dose‐finding results from a randomized controlled trial

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This study shows that tafoxiparin 300 mg can increase the rate of cervical ripening and the likelihood of spontaneous onset of labor, while also reducing the duration of labor in women achieving spontaneous onset of labor. The favorable safety profile of tafoxiparin suggests suitability for routine clinical use, including home administration.
Gunvor Ekman‐Ordeberg, Maria Jonsson, Marie Blomberg, Malin Melin, Ylva Stjernholm‐Vladic, Sebastian B. Gidlöf, Dag Wide‐Swensson, Kati Tihtonen, Inge C. Olsen, Lena Degling‐Wikingsson, Per Blom, Leena Rahkonen   +11 more
wiley   +1 more source

Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives

International Journal of Gynecology &Obstetrics, Volume 174, Issue 1, Page 70-78, July 2026.
Abstract Preterm birth occurs in approximately 10% of all pregnancies, and is not only the leading cause of neonatal mortality but also a major contributor to short‐ and long‐term morbidities due to immaturity. Preterm birth has also been linked to an increased risk of maternal cardiovascular and cerebrovascular diseases, making it a critical concern ...
Hikaru Imatake, Yoshitsugu Chigusa, Haruta Mogami, Satoshi Morita, Masaki Mandai   +4 more
wiley   +1 more source