Results 11 to 20 of about 1,520 (125)
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Activation of the voltage gated K+ channel KV7.1 leads to hyperpolarization shift of cell membranes. In a thorough SAR study eight positions of the lead compound (R)‐L3 were modified. (R)‐configuration, the indolylmethyl moiety in 3‐position and the 2‐fluorophenyl moiety in 5‐position appeared to be essential for high KV7.1 activation, whereas an OH ...
Florian Roßner +3 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 7, Page 3135-3158, 1 April 2026.Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes +4 more
wiley +1 more source
Pregnancy, Volume 2, Issue 2, March 2026.Abstract Non‐immune hydrops fetalis (NIHF) can result from a multitude of underlying causes, such as fetal genetic diseases, congenital anomalies, infections, fetal arrhythmias, placental tumors, monochorionic twin complications, and other disorders.
Society for Maternal‐Fetal Medicine (SMFM) +3 more
wiley +1 more source
Moving closer to an ideal tocolytic agent
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016 Background: In the modern era of obstetrics with years of extensive research, the incidence of preterm birth remains unchanged. Tocolysis, pharmacological inhibition of premature labor is the mainstay of treatment for preterm labor. Methods: This is a prospective study.
Nikita Gadam, Swarnalata Samal
openaire +2 more sources
Pediatrics International, Volume 68, Issue 1, January/December 2026.ABSTRACT Background Antenatal administration of magnesium sulfate (MgSO4) is employed for fetal neuroprotection, and its extended use for tocolysis remains prevalent in certain regions. The impact of MgSO4 on neonatal gastrointestinal function is contentious, with evidence indicating variability across subpopulations.
Takashi Okuno +5 more
wiley +1 more source
Respirology, Volume 31, Issue 1, Page 32-41, January 2026.This study updated safety evidence on ICS and LABA use in pregnant women with asthma. After adjusting confounders, there was no association between ICS or LABA use and adverse fetal outcomes. However, high‐dose ICS exposure was associated with a higher risk of congenital anomalies among ICS users.
Yea‐Chwen Wu +3 more
wiley +1 more source
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT In some cases, mitochondrial disease can remain undiagnosed until pregnancy reveals systemic symptoms. Clinicians should therefore consider this diagnosis in young patients presenting with diabetes, kidney disease, and hearing loss. Early diagnosis can improve maternal and fetal outcomes, particularly in high‐risk pregnancies complicated by ...
Tomoyuki Watanabe +2 more
wiley +1 more source
Health Science Reports, Volume 8, Issue 12, December 2025.ABSTRACT Background and Aims Preterm premature rupture of membranes (PPROM), a complication in approximately 4.5% of pregnancies, is a leading cause of preterm birth and significant perinatal morbidity. A substantial body of evidence implicates vaginal dysbiosis a departure from a healthy, Lactobacillus‐dominant microbiome in the pathogenesis of PPROM.
Maryam Alikamali +4 more
wiley +1 more source
Outcome of Vaginal Progesterone as a Tocolytic Agent: Randomized Clinical Trial [PDF]
ISRN Obstetrics and Gynecology, 2012 Vaginal progesterone has a potential beneficial effect in postponing of preterm labor by suppression of prostaglandins cascades. Although different studies evaluated the use of progesterone for preterm birth, the exact effect of which on prolongation of pregnancy remains unclear.
Saleh Gargari, Soraya +7 more
openaire +2 more sources
Antimicrobial prescribing guidelines for horses in Australia
Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt +18 more
wiley +1 more source