Results 31 to 40 of about 1,587 (161)

Hemi-Babim and Fenoterol as Potential Inhibitors of MPro and Papain-like Protease against SARS-CoV-2: An In-Silico Study

Medicina, 2022
The coronaviruses belong to the Coronaviridae family, and one such member, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing significant destruction around the world in the form of a global pandemic.
Ahmad Alzamami, Norah A. Alturki, Youssef Saeed Alghamdi, Shaban Ahmad, Saleh Alshamrani, Saeed A. Asiri, Mutaib M. Mashraqi   +6 more
doaj   +1 more source

Prenatal exposure to antihypertensive medication: A systematic review of neurodevelopmental and educational outcomes

JCPP Advances, EarlyView.
This systematic review investigated the association of prenatal exposure to antihypertensive medication with longer‐term poor neurodevelopmental outcomes by evaluating the findings from existing literature. We undertook a systematic review of previous studies looking specifically at neurodevelopmental outcomes in children.
Shrifah Alkhalaf, Sarjit Singh, Jill P. Pell, Scott M. Nelson, Daniel F. Mackay, Michael Fleming   +5 more
wiley   +1 more source

Associations of GNAS and RGS Gene Polymorphisms with the Risk of Ritodrine-Induced Adverse Events in Korean Women with Preterm Labor: A Cohort Study

Pharmaceutics, 2022
Ritodrine, a β2-adrenergic receptor agonist, is among most commonly prescribed tocolytic agents. This study aimed to evaluate the associations of single nucleotide polymorphisms in GNAS, RGS2, and RGS5 with the risk of ritodrine-induced adverse events ...
Eun-Jeong Jang, Young-Ju Kim, Han-Sung Hwang, Jeong Yee, Hye-Sun Gwak   +4 more
doaj   +1 more source

A Rare Constellation of Peripartum Cardiomyopathy Manifesting With Multiple Thromboembolic Phenomena in a 15‐Year‐Old

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT A 15‐year‐old postpartum primipara presented at 19 days with aphasia, right hemiparesis, chest pain, and dyspnea. Diagnostics confirmed concurrent cardioembolic stroke and pulmonary embolism secondary to peripartum cardiomyopathy (ejection fraction 29%).
Reuben E. Mkama, Bibiana Kazaura, Theresia E. Lutufyo, Baraka E. Mrisho, Hery O. Kimwela, Marco E. Nyakasalule, Ronald M. Costantini, Eliya Msemwa, Florence Malamso, George Assenga, Julius Kinyange, Josephine R. Laswai, Fabian M. Kamana, Godfery Malangwa, David S. Mazengo, Raymond Leiya, Andrea S. Hondo, Masuma Gulamhussein, Happiness J. Mathew, Paul P. Mwasapi, Phillip S. Muhochi, Hakolo L. Mgaya, Moa E. Kalunga, Brendan P. Shayo, Amani E. Senso, Leonia N. Ndakamaze, Tuzo Lyuu, Anna A. Sanga, Rosemary P. Minja, Deusdedit Ndilanha, Emmanuel J. Magandi, Nkulikiye Kanani, Anthony J. Gyunda, Immaculate R. Goima, Justus L. Ishengoma, Janet L. Mtenga, Flora N. Ndobho, Kigocha L. Okengo, Paschal N. Kulwijila, Pius C. Njingo   +39 more
wiley   +1 more source

Calcium Channel Blockers as Tocolytics: Principles of Their Actions, Adverse Effects and Therapeutic Combinations

Pharmaceuticals, 2013
Dihydropyridine Ca2+ channel blockers (CCBs) are widely accepted in the treatment of premature labour. Their mechanism of action in tocolysis involves the blockade of L-type Ca2+ channels, influenced by the Ca2+-activated K+ channels, beta-adrenergic ...
Róbert Gáspár, Judit Hajagos-Tóth
doaj   +1 more source

Twin-twin transfusion syndrome - diagnosis and prognosis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2003
Twin-twin transfusion syndrome is a serious complication of monozygotic, monochorionic, diamniotic twins resulting from transplacental vascular communications.
Hajrić-Egić Amira, Miković Željko, Filimonović Dejan, Ćirović Anka   +3 more
doaj   +1 more source

Priming of labor with tafoxiparin in nulliparous term pregnant women with unripe cervix—Proof‐of‐concept and dose‐finding results from a randomized controlled trial

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 8, Page 1566-1577, August 2026.
This study shows that tafoxiparin 300 mg can increase the rate of cervical ripening and the likelihood of spontaneous onset of labor, while also reducing the duration of labor in women achieving spontaneous onset of labor. The favorable safety profile of tafoxiparin suggests suitability for routine clinical use, including home administration.
Gunvor Ekman‐Ordeberg, Maria Jonsson, Marie Blomberg, Malin Melin, Ylva Stjernholm‐Vladic, Sebastian B. Gidlöf, Dag Wide‐Swensson, Kati Tihtonen, Inge C. Olsen, Lena Degling‐Wikingsson, Per Blom, Leena Rahkonen   +11 more
wiley   +1 more source

Atrial Fibrillation as a Rare Complication of the Use of Nifedipine as a Tocolytic Agent: A Case Report and Review of the Literature

Case Reports in Obstetrics and Gynecology, 2018
Calcium channel blockers are commonly used tocolytic agents on Labor and Delivery units worldwide as part of the management of preterm labor. Despite their overall reassuring safety profile, rare cardiovascular complications have been reported.
Nikolina P. Docheva, Emily D. Slutsky, Roger Sandelin, James W. Van Hook   +3 more
doaj   +1 more source

COMPAREMENT OF LOCALIZA ATOSIBAN AND HEXOPRENALINE IN PREMATURE DELIVERY BEFORE 32 AND AFTER 32 WEEKS OF PREGNANCY

Медицинский совет, 2017
The aim of the study was to compare the efficacy of tocolytic agents - hexoprenaline and atosiban taking into account the gestational age.Patients and methods.
O. R. Baev, O. N. Vasilchenko, A. O. Karapetyan, M. O. Baeva   +3 more
doaj   +1 more source

Structure–Activity Relationship Study on Ligands Activating the Voltage‐Gated Potassium Channel KV7.1

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Activation of the voltage gated K+ channel KV7.1 leads to hyperpolarization shift of cell membranes. In a thorough SAR study eight positions of the lead compound (R)‐L3 were modified. (R)‐configuration, the indolylmethyl moiety in 3‐position and the 2‐fluorophenyl moiety in 5‐position appeared to be essential for high KV7.1 activation, whereas an OH ...
Florian Roßner, Judith Schmidt, Guiscard Seebohm, Bernhard Wünsch   +3 more
wiley   +1 more source