Results 41 to 50 of about 41,743 (197)

Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis. [PDF]

PLoS ONE, 2017
We evaluated the efficacy and safety of tofacitinib in patients with rheumatoid arthritis (RA) in a real-world setting.Seventy consecutive patients, for whom tofacitinib was initiated between November 2013 and May 2016, were enrolled.
Naoki Iwamoto, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Ayako Nishino, Yoshiro Horai, Tomohiro Koga, Shin-Ya Kawashiri, Toshiyuki Aramaki, Kunihiro Ichinose, Yasuko Hirai, Mami Tamai, Hideki Nakamura, Kaoru Terada, Tomoki Origuchi, Katsumi Eguchi, Yukitaka Ueki, Atsushi Kawakami   +19 more
doaj   +1 more source

Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs

European Journal of Medicinal Chemistry Reports, 2022
Tofacitinib (CP-690,550), an approved Janus kinase (JAK) inhibitor, has been proven highly efficacious in treating rheumatoid arthritis (RA). Unfortunately, tofacitinib's clinical application has been limited by adverse side effects that arise from its ...
Viola Previtali, Ulrik Bering Keiding, Asger Hegelund Olsen, Jorge Peiró Cadahía, Anne Skovsbo Clausen, Andreas Kjaer, Thomas Lars Andresen, Anders Elias Hansen, Mads Hartvig Clausen   +8 more
doaj   +1 more source

Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

Frontiers in Immunology, 2021
ObjectiveCurrent knowledge on the actions of tofacitinib on cytokine signaling pathways in rheumatoid arthritis (RA) is based on in vitro studies. Our study is the first to examine the effects of tofacitinib treatment on Janus kinase (JAK) - signal ...
Maaria Palmroth, Krista Kuuliala, Ritva Peltomaa, Anniina Virtanen, Antti Kuuliala, Antti Kurttila, Anna Kinnunen, Marjatta Leirisalo-Repo, Olli Silvennoinen, Olli Silvennoinen, Olli Silvennoinen, Pia Isomäki, Pia Isomäki   +12 more
doaj   +1 more source

Plasma Immunoglobulin A and intestinal ultrasound: Novel indicators for disease activity monitoring in inflammatory bowel disease—Insights from a Taiwan cohort

Advances in Digestive Medicine, EarlyView.
Abstract Intestinal ultrasound (IUS) is a non‐invasive imaging method used to evaluate bowel wall inflammation and monitor disease activity in inflammatory bowel disease (IBD) patients. Both the European Crohn's and Colitis Organization and the American Gastroenterological Association endorse IUS for monitoring disease activity and identifying ...
Yu‐Lin Chen, Cheng‐Kuo Chen, Po‐Ju Huang, Hsing‐Hung Cheng, Wang‐De Hsiao, Pin‐Chun Huang, Tsung‐Lin Hsieh, Jia‐Sheng Wen, Tsung‐Yu Tsai   +8 more
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism

Frontiers in Pharmacology
This work aimed to explore the mechanisms underlying the interaction of the active furanocoumarins in P. corylifolia on tofacitinib both in vivo and in vitro. The concentration of tofacitinib and its metabolite M8 was determined using UPLC-MS/MS.
Yu Wang, Quan Zhou, Huihui Wang, Wei Song, Jianfeng Wang, Abdullah Al Mamun, Peiwu Geng, Yunfang Zhou, Shuanghu Wang   +8 more
doaj   +1 more source

Serious Infections in Offspring Exposed to Tumor Necrosis Factor Inhibitors During Pregnancy: Comparison of Timing During Pregnancy and Placental Transfer Ability

Arthritis &Rheumatology, EarlyView.
Objective We evaluated serious infection risk in offspring exposed to tumor necrosis factor inhibitors (TNFi) in utero, separated by TNFi timing and placental transfer ability. Methods Using MarketScan (2011–2021), we identified offspring born to mothers with chronic inflammatory diseases.
Leah K. Flatman, Sasha Bernatsky, Yvan St‐Pierre, Marie‐Eve Beauchamp, Isabelle Malhamé, Anick Bérard, Évelyne Vinet   +6 more
wiley   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Tofacitinib Ameliorates Lupus Through Suppression of T Cell Activation Mediated by TGF-Beta Type I Receptor

Frontiers in Immunology, 2021
Autoreactive T cells play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). TGF-β type I receptor (TGFβRI) is pivotal in determining T cell activation.
Qing Yan, Qing Yan, Weiwei Chen, Weiwei Chen, Hua Song, Xianming Long, Zhuoya Zhang, Xiaojun Tang, Hongwei Chen, He Lin, Lingyun Sun, Lingyun Sun   +11 more
doaj   +1 more source