Results 61 to 70 of about 1,815 (184)

Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus in real‐world practice: Results of 12‐month interim analysis of a long‐term post‐marketing surveillance study (J‐STEP/LT)

Journal of Diabetes Investigation, 2020
Aims/Introduction Due to the paucity of tofogliflozin data, we assessed the safety and effectiveness of tofogliflozin among Japanese patients with type 2 diabetes mellitus in the clinical setting, stratifying the patients by age, sex, estimated ...
Kazunori Utsunomiya, Masayuki Senda, Seigo Kakiuchi, Hiroyuki Kameda, Masahiro Tamura, Yuji Kurihara, Ryoji Gunji, Shoko Fujii, Kohei Kaku   +8 more
doaj   +1 more source

Massive X-ray screening reveals two allosteric drug binding sites of SARS-CoV-2 main protease [PDF]

, 2020
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health problems and economical challenges for mankind. To date, no effective drug is available to directly treat the disease and prevent virus spreading.
Alves Franca, Bruno, Andaleeb, Hina, Awel, Salah, Barthelmess, Miriam, Beck, Tobias, Bento, Isabel, Betzel, Christian, Boger, Juliane, Borenkov, Gleb, Brehm, Wolfgang, Brognaro, Hévila, Chapman, Henry N., Chari, Ashwin, Cox, Russell, Domaracky, Martin, Doyle, John J., Dunkel, Ilona, Ehrt, Christiane, Ellinger, Bernhard, Escudero-Pérez, Beatriz, Ewert, Wiebke, Falke, Sven, Feiler, Christian, Fernández-García, Yaiza, Fischer, Pontus, Fleckenstein, Holger, Galchenkova, Marina, Garcia Alai, Maria Marta, Gelisio, Luca, Gevorkov, Yaroslav, Gieseler, Henry, Ginn, Helen, Gribbon, Phil, Groessler, Michael, Guicking, Filip, Günther, Christian, Günther, Sebastian, Günther, Stephan, Hakanpää, Johanna, Han, Huijong, Hennicke, Vincent, Hilgenfeld, Rolf, Hinrichs, Winfried, Hänle, Anna, Karničar, Katarina, Karpics, Ivars, Knoska, Juraj, Kopicki, Janine, Koua, Faisal, Krichel, Boris, Kuzikov, Maria, Lane, Thomas J., Li, Chufeng, Lieske, Julia, Loboda, Jure, Lorenzen, Kristina, Lourdu, P. Xavier, Meents, Alke, Mehrabi, Pedram, Meier, Susanne, Melo, Diogo, Meyer, Jan, Monteiro, Diana C. F., Niebling, Stephan, Norton-Baker, Brenna, Oberthuer, Dominik, Panneerselvam, Saravanan, Pearson, Arwen R., Peck, Ariana, Peña Murillo, Gisel E., Pletzer-Zelgert, Jonathan, Pompidor, Guillaume, Rahmani Mashhour, Aida, Rarey, Matthias, Reinke, Patrick Y. A., Rogers, Cromarte, Saouane, Sofiane, Schlünzen, Frank, Schmidt, Christina, Schneider, Thomas R., Schubert, Robin, Schulz, Eike C., Schwinzer, Martin, Seychell, Brandon, Srinivasan, Vasundara, Sun, Xinyuanyuan, Tidow, Henning, Tolstikova, Aleksandra, Trost, Fabian, Turk, Dusan, Uetrecht, Charlotte, Ullah, Najeeb, Usenik, Aleksandra, von Stetten, David, Weiss, Manfred S., Werner, Nadine, White, Thomas, Wolf, Markus, Wollenhaupt, Jan, Yefanov, Oleksandr, Zaliani, Andrea, Zhang, Linlin   +101 more
core   +5 more sources

The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus

Journal of International Medical Research, 2018
Objective To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) Methods This retrospective study involved mainly elderly patients with T2DM who had ...
Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichirou Ishigami, Masaru Kohori, Kunihiro Mae, Ryusho Sangen, Daisuke Usuda, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Akihiro Fukuda, Hitoshi Saito, Tsugiyasu Kanda, Masashi Okuro   +14 more
doaj   +1 more source

Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Weight in Type 2 Diabetes Mellitus and Therapeutic Regimen Recommendation

Journal of Diabetes Research, 2022
Aims. The present study is aimed at exploring the effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on weight in type 2 diabetes mellitus (T2DM) and therapeutic regimen recommendations. Methods. 20,019 patients with T2DM were enrolled.
Dong-Dong Wang, Yi-Zhen Mao, Yang Yang, Tian-Yun Wang, Ping Zhu, Su-Mei He, Xiao Chen   +6 more
doaj   +1 more source

Cardioprotective Effects of Sodium-Glucose Cotransporter Subtype Inhibition on Ischemic and Pharmacological Preconditioning [PDF]

Cureus
Nagasaki University (長崎大学)博士(医学)Background: Sodium-glucose cotransporter (SGLT) 2 inhibitors partially inhibit SGLT1 expression; however, whether a clinical dose of SGLT2 inhibitor abrogates ischemic preconditioning (IPC) is unknown, and the ...
Egashira T, Ichinomiya T, Yokoyama A, Matsumoto S, Higashijima U, Sekino M, Murata H, Yoshitomi O, Sato S, Hara T.   +9 more
europepmc   +3 more sources

Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Concurrent Type 2 Diabetes Mellitus and Non-Alcoholic Steatohepatitis: A Review of the Evidence [PDF]

, 2021
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and more than half of individuals diagnosed with type 2 diabetes concurrently present with NAFLD.
Yabiku, Koichi
core   +1 more source

Effects of Tofogliflozin and Anagliptin Alone or in Combination on Glucose Metabolism and Atherosclerosis-Related Markers in Patients with Type 2 Diabetes Mellitus

Clinical Pharmacology: Advances and Applications, 2023
Shosaku Nomura,1 Akira Shouzu,2 Takehito Taniura,3 Yoshinori Okuda,4 Seitaro Omoto,5 Masahiko Suzuki,6 Tomoki Ito,7 Nagaoki Toyoda8 1Center of Thrombosis and Hemostasis, Kansai Medical University Medical Center, Moriguchi, Japan; 2Division of Diabetes ...
Nomura S, Shouzu A, Taniura T, Okuda Y, Omoto S, Suzuki M, Ito T, Toyoda N   +7 more
doaj  

Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Endothelial Function: A Systematic Review of Preclinical Studies [PDF]

, 2020
IntroductionWhile the beneficial effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on cardiovascular and renal outcomes are recognized, their direct effects on endothelial function remain unclear.
Alshnbari, Afnan S., Idris, Iskandar, Millar, Sophie A., O’Sullivan, Saoirse E.   +3 more
core   +2 more sources

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus treated in real‐world clinical practice: Results of a 36‐month post‐marketing surveillance study (J‐STEP/LT)

Journal of Diabetes Investigation, 2021
Aims/Introduction Tofogliflozin is a sodium–glucose cotransporter 2 (SGLT2) inhibitor that lowers plasma glucose levels by enhancing urinary glucose excretion.
Kazunori Utsunomiya, Ryusuke Koshida, Seigo Kakiuchi, Masayuki Senda, Shoko Fujii, Yuji Kurihara, Ryoji Gunji, Kohei Kaku   +7 more
doaj   +1 more source