Results 91 to 100 of about 254,354 (315)

Reexamining Ophthalmic Drugs, Safety and Tolerability in Phase 1 Clinical Trials

Therapeutics and Clinical Risk Management, 2021
Patricia Muñoz-Villegas, Andrea A Navarro-Sánchez, Alejandra Sánchez-Ríos, Oscar Olvera-Montaño, Leopoldo M Baiza-Durán Medical Affairs Department, Laboratorios Sophia, S.A.
Muñoz-Villegas P, Navarro-Sánchez AA, Sánchez-Ríos A, Olvera-Montaño O, Baiza-Durán LM   +4 more
doaj  

Efficacy and tolerability of Laxatan® Granulat in patients with chronic constipation

, 2009
Joerg Gruenwald, Regina Busch, Christine BentleyAnalyze and Realize AG, Berlin, GermanyBackground: On average 12% of the population worldwide suffer from acute or chronic constipation.
Christine Bentley, Joerg Gruenwald, Regina Busch   +2 more
core  

Effectiveness, tolerability and practical application of the newer generation anti-obesity medications [PDF]

, 2016
Objective: Comparison of the efficacy and tolerability of five newer anti-obesity medications to guide clinical decision making, examining bupropion–naltrexone combination, liraglutide, lorcaserin, orlistat, and phentermine–topiramate combination ...
Thomas L Schwartz, Jeffrey S MacDaniels
core   +1 more source

Rare‐Earth–Functionalized Carbon Dot Hydrogels as Mechanically Robust Antibacterial Wound Dressings

Advanced Healthcare Materials, EarlyView.
The schematic depicts a dynamically cross‐linked PVA hydrogel network in which reversible borate ester bonds and hydrogen‐bonding interactions integrate lanthanum‐doped carbon dots (La‐CDs) and dipotassium glycyrrhizinate (DPG) to form a mechanically robust, multifunctional matrix.
Shih‐Han Tsai, Ramadhass Keerthika Devi, Muthusankar Ganesan, Guo‐Ping Chang Chien, Chun Che Lin   +4 more
wiley   +1 more source

Schizophrenia relapse, patient considerations, and potential role of lurasidone

Patient Preference and Adherence, 2016
Leslie Citrome Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA Abstract: When treating persons with schizophrenia, delaying time to relapse is a main goal.
Citrome L
doaj  

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Adverse reactions and tolerability of high-dose sublingual allergen immunotherapy

, 2016
Angel Moral,1 Victoria Moreno,2 Francisco Girón,3 David El-Qutob,4 José D Moure,5 Manuel Alcántara,6 Antonia Padial,7 Alberto G Oehling,8 Carmen Millán,9 Fernando de la Torre10 1Allergy Service, Hospital Virgen del Valle ...
Moral A, Oehling AG, Millán C, El-Qutob D, Moreno V, Alcántara M, Padial A, Girón F, Moure JD, de la Torre F   +9 more
core  

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects

Drug Design, Development and Therapy
Yun Liu,1,2,* Chengyin Yu,1– 3,* Yifan Zhang,3 Zhifu Xie,3 Yating Wang,1,2 Hongjie Qian,1,2 Liyu Liang,1,2 Yanmei Liu,1,2 Qian Chen,1,2 Jingying Jia,1,2 Sai Yan,4 Xiaoyin Lai,4 Wei Li,4 Jingya Li,3 Yangming Zhang,4 Fajun Nan,3 Chen Yu1,2 ...
Liu Y, Yu C, Zhang Y, Xie Z, Wang Y, Qian H, Liang L, Liu Y, Chen Q, Jia J, Yan S, Lai X, Li W, Li J, Zhang Y, Nan F, Yu C   +16 more
doaj  

Efficacy, Tolerability and Adverse Effects of Triple Fixed Dose Combination Brimonidine–Brinzolamide–Timolol Ophthalmic Suspension in Primary Open Angle Glaucoma: A Retrospective Study

Delhi Journal of Ophthalmology
Purpose: To evaluate the efficacy and tolerability of recently introduced triple fixed dose combination (TFC) of brimonidine–brinzolamide–timolol (BBTFC) in patients with primary open angle glaucoma (POAG).
Hina Kounsar, Swati Singh, Harsh Kumar
doaj   +1 more source