Results 71 to 80 of about 190,847 (266)
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
Reexamining Ophthalmic Drugs, Safety and Tolerability in Phase 1 Clinical Trials
Therapeutics and Clinical Risk Management, 2021 Patricia Muñoz-Villegas, Andrea A Navarro-Sánchez, Alejandra Sánchez-Ríos, Oscar Olvera-Montaño, Leopoldo M Baiza-Durán Medical Affairs Department, Laboratorios Sophia, S.A.
Muñoz-Villegas P +4 more
doaj
Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths
Advanced Science, EarlyView.Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears +5 more
wiley +1 more source
Schizophrenia relapse, patient considerations, and potential role of lurasidone
Patient Preference and Adherence, 2016 Leslie Citrome Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA Abstract: When treating persons with schizophrenia, delaying time to relapse is a main goal.
Citrome L
doaj
Advanced Science, EarlyView.Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan +8 more
wiley +1 more source
Drug Design, Development and TherapyYun Liu,1,2,* Chengyin Yu,1– 3,* Yifan Zhang,3 Zhifu Xie,3 Yating Wang,1,2 Hongjie Qian,1,2 Liyu Liang,1,2 Yanmei Liu,1,2 Qian Chen,1,2 Jingying Jia,1,2 Sai Yan,4 Xiaoyin Lai,4 Wei Li,4 Jingya Li,3 Yangming Zhang,4 Fajun Nan,3 Chen Yu1,2 ...
Liu Y +16 more
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Use of depakine chronosphere as a first monotherapy to treat epilepsy in children
Неврология, нейропсихиатрия, психосоматика, 2010 Objective: to obtain additional Russian data on the efficacy of Depakine Chronosphere as first-line monotherapy in the treatment of epilepsy in children without epileptic encephalopathy.Subjects and methods.
E. D. Belousova, A. Yu. Ermakov
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Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Delhi Journal of OphthalmologyPurpose: To evaluate the efficacy and tolerability of recently introduced triple fixed dose combination (TFC) of brimonidine–brinzolamide–timolol (BBTFC) in patients with primary open angle glaucoma (POAG).
Hina Kounsar, Swati Singh, Harsh Kumar
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