Results 71 to 80 of about 341,593 (314)

Evaluation of efficacy and tolerability of TCIC-001 for bowel preparation prior to colonoscopy: an exploratory randomized controlled clinical trial

Zhongguo Linchuang Yixue
ObjectiveTo compare the efficacy and tolerability of the novel bowel-cleansing agent TCIC-001 and the traditional polyethylene glycol (PEG) regimen for bowel preparation prior to colonoscopy. MethodsProspective inclusion of 62 patients who were scheduled
Baohui SONG, Xiaolong ZHUANG, BAHETINUER Jiashaer, Xiaoyue XU, Jiaxin XU, Danfeng ZHANG, Yunshi ZHONG, Pinghong ZHOU, Mingyan CAI   +8 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients. [PDF]

, 2016
This study aimed to investigate the pharmacokinetics (PK), safety, and tolerability of a single dose of ceftazidime-avibactam in pediatric patients. A phase I, multicenter, open-label PK study was conducted in pediatric patients hospitalized with an ...
Armstrong, Jon, Arrieta, Antonio, Bishai, Raafat, Bradley, John S, Das, Shampa, Delair, Shirley, Edeki, Timi, Holmes, William C, Li, Jianguo, Moffett, Kathryn S, Mukundan, Deepa, Perez, Norma, Romero, José R, Speicher, David, Sullivan, Janice E, Zhou, Diansong   +15 more
core  

Tolerability and Safety of Miltefosine for the Treatment of Cutaneous Leishmaniasis

Tropical Medicine and Infectious Disease
Miltefosine, an orally administered drug, is an important component of the therapeutic arsenal against visceral and mucosal forms of leishmaniasis. However, data regarding the safety and tolerability of miltefosine treatment for cutaneous leishmaniasis ...
Nadav Astman, Chen Arbel, Oren Katz, Aviv Barzilai, Michal Solomon, Eli Schwartz   +5 more
doaj   +1 more source

Open-Label Extension Study Comparing Latanoprost 0.005% Without vs With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension

Clinical Ophthalmology, 2022
Bridgitte Shen Lee,1 Ranjan Malhotra,2 Kenneth Sall,3 Brittany Mitchell,4 James Peace5 1Vision Optique, Houston, TX, USA; 2Ophthalmology Associates, St. Louis, MO, USA; 3Sall Research Medical Center, Inc., Artesia, CA, USA; 4Medical Affairs North America,
Shen Lee B, Malhotra R, Sall K, Mitchell B, Peace J   +4 more
doaj  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Demonstrating adequate safety for a concrete column exposed to fire, using probabilistic methods [PDF]

, 2019
Demonstrating adequate safety for exceptional designs and new design applications requires an explicit evaluation of the safety level, considering the uncertainties associated with the design. The recently published PD 7974-7:2019 provides five routes to
Elhami Khorasani, Negar, Gernay, Thomas, Hopkin, Danny, Van Coile, Ruben   +3 more
core  

Phase I dose-escalation trial of the oral AKT inhibitor uprosertib in combination with the oral MEK1/MEK2 inhibitor trametinib in patients with solid tumors. [PDF]

, 2020
PurposeThis study aimed to determine the safety, tolerability, and recommended phase II doses of trametinib plus uprosertib (GSK2141795) in patients with solid tumors likely to be sensitive to MEK and/or AKT inhibition.MethodsThis was a phase I, open ...
Becerra, Carlos, D'Amelio, Anthony M, Ellis, Catherine, Gauvin, Jennifer, Gonzalez, Rene, Heist, Rebecca S, Ibrahim, Nageatte, Kalyana-Sundaram, Shanker, Kleha, Joseph F, Kurzrock, Razelle, Leonowens, Cathrine, Means-Powell, Julie, Tan, Antoinette R, Tolcher, Anthony W, Valero, Vincente, Wang, Chenxi, Werner, Theresa L, Yan, Li   +17 more
core  

How subjective and non-physical parameters affect occupants’ environmental comfort perception [PDF]

, 2018
Employees’ wellbeing and comfort perception demonstrated to largely influence their productivity and tolerability of slight thermal discomfort conditions in the working spaces.
Castaldo, Veronica Lucia, Cotana, Franco, De Giorgio, Francesco, Pigliautile, Ilaria, Pisello, Anna Laura, Rosso, Federica   +5 more
core   +1 more source

Рrospective multicenter study of treatment efficacy, safety, and quality of life in a large cohort of patients with inborn errors of immunity receiving subcutaneous immunoglobulin by the rapid push method

Frontiers in Immunology
Subcutaneous immunoglobulin (SCIG) preparations are widely used in patients with inborn errors of immunity (IEI), with proven efficacy and good tolerance.
Asmik Avedova, Elena Deripapa, Yulia Rodina, Anna Mukhina, Elena Latysheva, Daria Yukhacheva, Vasily Burlakov, Nellie Kan, Daria Bogdanova, Anna Moiseeva, Natalia Kuzmenko, Zoya Nesterenko, Ekaterina Deordieva, Anna Ogneva, Victoria Bludova, Anna Roppelt, Daria Fomina, Natalia Zinovieva, Yulia Sevostyanova, Linara Kalmeteva, Dilara Prolygina, Lyudmila Barycheva, Olga Selezneva, Natalya Shakhova, Olga Laba, Elena Vlasova, Alla Gorenkova, Elena Timofeeva, Olga Trusova, Marina Guseva, Natalya Yudina, Evgeniya Grevtseva, Asya Ibisheva, Zema Bambaeva, Dina Mashkovskaya, Svetlana Isakova, Almazia Shakirova, Ekaterina Selina, Tatyana Shilova, Elena Zubova, Iman Khabaeva, Ekaterina Kitova, Anastasia Mandzhieva, Svetlana Starikova, Tatyana Pavlova, Elvira Tyulyakova, Pavel Levin, Nikolay Grachev, Anna Shcherbina   +48 more
doaj   +1 more source