Results 71 to 80 of about 955,883 (263)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Design of Parabolic Off-Axis Reflector Optical System for Large Aperture Single Star Simulators

Applied Sciences
This study proposes a parabolic off-axis reflective optical system design method to reduce the wave aberration of the optical system of a large aperture single star simulator and improve the optical system’s imaging quality.
Tianyu Gao, Gaofei Sun, Guoyu Zhang, Zongyu Du, Qiang Liu, Qian Deng, Siwen Chen, Jierui Zhang   +7 more
doaj   +1 more source

Study of the Ultimate Error of the Axis Tolerance Feature and Its Pose Decoupling Based on an Area Coordinate System

Applied Sciences, 2018
Manufacturing error and assembly error should be taken into consideration during evaluation and analysis of accurate product performance in the design phase.
Qungui Du, Xiaochen Zhai, Qi Wen
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Multibody Dynamics for Assessing Tolerance Effects in Roller-Bearing-Supported Rings

Designs
The accurate motion of roller-bearing-supported rings is critically influenced by shape and positional tolerances, which are often underestimated in conventional modeling approaches.
Ulyana Konopada, Giulia Pascoletti, Mauro Corrado, Elisabetta Maria Zanetti   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Full-Space Modeling of Geometric Variation Propagation in a Multi-Axis Milling System Considering Local Parallel Chains

Machines
The end-effector accuracy of a multi-axis milling system is primarily affected by assembly errors and deformation errors induced by low structural stiffness.
Shun Liu, Yang Xiang, Qunfei Gu, Yongqiao Jin, Sun Jin   +4 more
doaj   +1 more source

Enzymatic properties and inhibition tolerance analysis of key enzymes in β-phenylethanol anabolic pathway of Saccharomyces cerevisiae HJ. [PDF]

Synth Syst Biotechnol, 2023
Yang Q, Liu S, Zhao Y, Han X, Chang R, Mao J.   +5 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Tolerance Analysis of Mechanical Parts

Tehnički Glasnik, 2020
The determination of tolerances has a huge impact on the price and quality of products. The objective of tolerance analysis is to provide the widest possible tolerance range of parts, without disturbing the functionality of the assembly.
Živko Kondić, Đuro Tunjić, Leon Maglić, Amalija Horvatić Novak   +3 more
doaj