Results 101 to 110 of about 1,514,542 (307)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Approaches to Software Based Fault Tolerance - A Review [PDF]
Computer Science Journal of Moldova, 2005 This paper presents a review work on various approaches to software based fault tolerance. The aim of this paper is to cover past and present approaches to software implemented fault tolerance that rely on both software design diversity and on single
Goutam Kumar Saha
doaj
Distributed intelligent robotics : research & development in fault-tolerant control and size/position identification : a thesis presented in partial fulfilment of the requirements for the degree of Master of Engineering in Computer Systems Engineering at Massey University [PDF]
, 2002 This thesis presents research conducted on aspects of intelligent robotic systems. In the past two decades, robotics has become one of the most rapidly expanding and developing fields of science.
Subramaniam, Karthikeya Krishna
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A fault-tolerant intelligent robotic control system [PDF]
This paper describes the concept, design, and features of a fault-tolerant intelligent robotic control system being developed for space and commercial applications that require high dependability.
Marzwell, Neville I., Tso, Kam Sing
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
RESEACH OF THREE-DIMENSIONAL CRACK GROWTH BASED ON DISK OF TURBO-SHAFT ENGINE
Jixie qiangdu, 2018 Three-dimensional crack growth was analyzed using damage tolerance design-based method and Franc3D to find cause of unexpected fatigue test failure of a turboshaft engine disk,showing that the crack propagation life was shorter than the test inspection ...
AI ShuMin +3 more
doaj
Reducing manufacturing costs: the dynamic tolerance system
Cogent Engineering, 2019 Can tolerance limits in production be extended without violating the specifications of design and development? Adherence to tolerances is crucial for the technical quality of a manufactured good.
Anselm Lorenzoni +2 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Tolerant Paternalism: Pro-ethical Design as a Resolution of the Dilemma of Toleration [PDF]
Science and Engineering Ethics, 2015 Toleration is one of the fundamental principles that inform the design of a democratic and liberal society. Unfortunately, its adoption seems inconsistent with the adoption of paternalistically benevolent policies, which represent a valuable mechanism to improve individuals' well-being.
openaire +2 more sources