Results 61 to 70 of about 457 (170)

A comparative study on safety and efficacy of tolperisone with etodolac and thiocolchicoside with etodolac in patients of acute low back pain with musculoskeletal spasm

open access: yes, 2019
Background: Low back pain is one of the most common health problems in society which leads to considerable disability, loss of work days, and puts a huge burden on socioeconomic and healthcare system.
Garg, Tanu, Yadav, Vijay K.
core   +1 more source

Complex therapy of musculoskeletal pain: the role of centrally acting muscle relaxants

open access: yesСовременная ревматология
Chronic pain is the main manifestation of musculoskeletal diseases (MSDs), leading to deterioration of quality of life and loss of ability to work. The importance of this problem is determined by the widespread prevalence of MSDs, osteoarthritis (OA ...
A. E. Karateev   +11 more
doaj   +1 more source

PP124—Pharmacokinetics of tolperisone in relation to CYP2C19 genotypes

open access: yesClinical Therapeutics, 2013
e54 Volume 35 Number 8S to filter for potential phenotype-relevant target genes. After cloning 3’-UTR sequences containing predicted miRNA binding sites into psiCHECK2 or pmiRGLO vectors reporter gene assays were performed to confirm RNA interference of selected candidate miRNAs with their respective target genes.
Byeon, J.-Y.   +6 more
openaire   +1 more source

Development and Validation of a Precise, Single HPLC Method for the Determination of Tolperisone Impurities in API and Pharmaceutical Dosage Forms

open access: yes, 2012
A novel, sensitive, stability-indicating HPLC method has been developed for the quantitative estimation of Tolperisone-related impurities in both bulk drugs and pharmaceutical dosage forms.
Srinivas ARUTLA   +5 more
core   +1 more source

Factors affecting the results of analgesic therapy. Results of the Russian multicentre study of NOTE (NSAID: Open-label Trial of Efficacy) [PDF]

open access: yesТерапевтический архив, 2018
Non-steroidal anti-inflammatory drugs (NSAIDs) are most popular medications for the treatment of pain in common musculoskeletal diseases such as osteoarthritis (OA) and non-specific low back pain (LBP). However, the factors affecting the effectiveness of
A E Karateev   +24 more
doaj   +1 more source

Muscle relaxants as alternative analgesics in the treatment of nonspecific back pain

open access: yesНеврология, нейропсихиатрия, психосоматика, 2017
Only 50% of patients treated for back pain achieve effective relief. This is to some extent due to physicians' insufficient knowledge about the therapeutic strategies recommended in most expert guidelines.
G. R. Tabeeva
doaj   +1 more source

MUSCLE RELAXANTS: ARE THEY NEEDED IN ANKYLOSING SPONDYLITIS?

open access: yesНаучно-практическая ревматология, 2016
Guidelines for the treatment of ankylosing spondylitis (AS) lack muscle relaxants. At the same time, the latter are used for combined therapy using nonsteroidal  anti-inflammatory drugs (NSAIDs)  in 53.1% of patients in an outpatient  setting.
T. V. Dubinina   +3 more
doaj   +1 more source

Formulation and Evaluation of Mouth Dissolving Tablets of Tolperisone

open access: yesPharmaceutical and Biosciences Journal, 2013
The present study was carried out to develop and evaluate mouth dissolving tablets of Tolperisone hydrochloride using superdisintegrants agents namely Crospovidone and Sodium starch glycolate in different ratio. Mouth dissolving tablets are solid dosage form containing medicinal substances which disintegrates rapidly, usually within a matter of seconds,
null Daljit Masih, null Rajesh Gupta
openaire   +1 more source

A COMPARATIVE STUDY ON EFFICACY AND SAFETY OF TOLPERISONE VERSUS TIZANIDINE IN PATIENTS SUFFERING FROM ACUTE LOW BACK PAIN WITH MUSCLE SPASM

open access: yes, 2021
OBJECTIVES: The objectives of this study were to compare the efficacy and safety of Tolperisone tablets 50 mg three times daily versus Tizanidine 2 mg tablets thrice daily for the treatment of acute low back pain with muscle spasm.
KHAN, ABDUL FAHEEM, PARVEEN, KHANETA
core  

DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR THE ESTIMATION OF TOLPERISONE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM

open access: yes, 2012
A rapid, specific and sensitive reverse phase high performance liquid chromatographic (RP-HPLC) method was developed for the determination of Tolperisone Hydrochloride (TOLP) in bulk and tablet dosage form.
Koladiya, Bhavesh Bhurabhai   +1 more
core   +1 more source

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